Eicosapentaenoic acid absorption

Other fatty acids as absorption enhancers have been reported. Ogiso et al. [112] demonstrated that lauric acid (C12) produced the largest increase in permeation rate, penetration coefficient, and partition coefficient of propranolol. Onuki et al. [113] reported that docosa-hexaenoic acid (DHA) has a strong insulin permeability enhancement effect and little toxicity, compared to oleic acid and eicosapentaenoic acid (EPA) using a water-in-oil-in-water (W/O/W) multiple emulsion with no or little mucosal damage. 

Hansen, J.B., Grimsgaard, S., Nilsen, H., Nordoy, A. and Bonaa, K.H. (1998) Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia. Lipids. 33 131-138. 

Sesamin has been associated with the reduction of serum and liver lipids (Hirose etal., 1991,1996 Ide etal., 2001 Yasumoto etal., 2001). Hirose etal. (1991) reported that sesamin decreased lymphatic absorption of cholesterol. Sesamin was found to be a promoter of hepatic fatty acid oxidation in rats (Ashakumary et al., 1999). Addition of a 1 1 mixture of sesamin and episesamin to the diet of rats (0.1-0.5% of total diet) promoted mitochondrial and peroxisomal palmitoyl coenzyme A (CoA) oxidation rates in a dose-dependent manner. Rats fed diets containing 0.5% sesamin had 2 fold higher mitochondrial activity and 10 fold higher peroxisomal activity than rats fed non-sesamin diets. Yasumoto et al. (2001) reported similar findings when a 20% sesame seed diet was fed to rats. These authors compared two experimental sesame seed lines (0730 and 0732) with the commercial cultivar Masekin. Both experimental seed lines enhanced mitochondrial and peroxisomal fatty acid oxidation rates, and were more effective than the commercial cultivar at reducing plasma triacylglycerol levels (Yasumoto et al., 2001). A study of the effects of dietary sesamin on the hepatic metabolism of arachidonic and eicosapentaenoic acids in rats showed similar increases in hepatic mitochondrial and peroxisomal fatty acid oxidation (Sawada et al., 2001). 

Boustani SEl, Colette C, Monnier L, Descomps B, Crastes de Paulet A, Mendy F (1987) Enteral absorption in man of eicosapentaenoic acid in different chemical forms. Lipids 22 711-714... 

Nordoy A, Barstad L. Connor Wl i, Hatcher L. Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am J Clin Nutr 1991 53 1185-1190. 

Christensen, M.S., Hoy, C.E., Becker, C.C., and Redgrave, T.G. 1995. Intestinal absorption and lymphatic transport of eicosapentaenoic, docosahexaenoic, and decanoic acids dependence on intramolecular triacylglycerols structure. Am. Clin. Nutr. 61 56-61. 

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