Effervescent tablets ascorbic acid

A comparison of the formation of carbon dioxide from effervescent tablets based on anhydrous citric acid, ascorbic acid or tartaric acid, and NaHCOs in stoichiometric proportions indicated that ascorbic acid and anhydrous citric acid behaved similarly. 

Ascorbic acid can be used as the acid source. The speed of release of carbon dioxide from a mixture of ascorbic acid and NaHCOs is comparable with that produced by citric or tartaric acid-NaHCOs combinations. Since ascorbic acid is less hygroscopic than citric and tartaric acid, using ascorbic acid as the only acid source makes it possible to produce effervescent tablets in a non-airconditional area. ... 

Effervescent tablets of ascorbic acid, 0.5-1 g, are well known. Other vitamins as well as calcium and some minerals have also been included. 

A combination of 4% polyethylene glycol (PEG) 6000 and 0.1% sodium stearyl fumarate proved to be a good lubricant for ascorbic acid tablets made by direct compression on a small scale. Sodium chloride, sodium acetate, and D,L-leucine (water-soluble lubricants) also have been suggested for effervescent tablets. ... 

Schmidt, P.C. Brogmann, B. Effervescent tablets choice of a new binder for ascorbic acid. Acta Pharm. Technol. 1988, 34, 22-26. 

Merckle and Kovar reported an assay of effervescent tablets (intact and powdered) by NIRS in transmittance and reflectance modes. Results of quantitative determination of acetylsalicylic acid (ASA) and ASA in combination with ascorbic acid and/or paracetamol were comparable in both transmittance and reflectance modes. Corti and associates described a NIR transmittance analysis of coated tablets, using both whole and milled tablets. 

Povidone K 25 and povidone K 30 are very good binders for effervescent tablets, as they dissolve rapidly in water to form a clear solution. This particularly applies to effervescent vitamin tablets, e.g. ascorbic acid tablets [368 b]. Tables 65 and 66 give formulations for ranitidine effervescent tablets and multivitamin effervescent tablets as typical examples that were developed on a laboratory scale. For the granulation of multivitamin preparations, it is always preferable to use a fluidized bed. 

A 1993 paper by Blanco et al. addressed concerns of laboratory manipulation of production samples prior to analysis [82], Two commercial preparations of ascorbic acid (vitamin C) were analyzed, including one granular product and one effervescent tablet. No less than five batches were used. 

Resvis XR effervescent tablets (Biofutura Pharma, Milan, Italy) Resveratrol, hesperidin, narirutin, L-ascorbic acid, vitamin B2, p-coumaric acid, caffeic acid, ferulic acid, sinapic acid, flufenamic acid (IS) CZE Three-factor CCD (Borate), ACN %, voltage Resolution, analysis time (47)... 

Pi (CH30+ Casa ) allows reading the pH which is 2.63. In effervescent tablets ASA is usually mixed with ascorbic acid, sodium dihydrogencitrate and citric acid, as well as with sodium hydrogen carbonate and disodium carbonate. If a tablet containing only 400 mg ASA and 240 mg vitamin C is dissolved in 150 mL water (this corresponds to 0.0148 mol ASA and 0.009 mol vitamin C) one can describe the solution with the help of the pH-logc, diagram shown in Fig. 66. 

The pH at Pj is 2.63. Because of the slightly less acidic ascorbic acid, some additional HsO" is produced and the pH wiU be below 2.63. In conunercial effervescent tablets, the above-mentioned added buffer systems keep the pH much higher, as the acids will be partially neutralized by the carbonates. 

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