Ranitidine effervescent tablets

Povidone K 25 and povidone K 30 are very good binders for effervescent tablets, as they dissolve rapidly in water to form a clear solution. This particularly applies to effervescent vitamin tablets, e.g. ascorbic acid tablets [368 b]. Tables 65 and 66 give formulations for ranitidine effervescent tablets and multivitamin effervescent tablets as typical examples that were developed on a laboratory scale. For the granulation of multivitamin preparations, it is always preferable to use a fluidized bed. 

Ranitidine is available either in a liquid form (75 mg/5 mL syrup) or as effervescent tablets that may be dissolved in water. 

Excipients such as mannitol can affect small intestinal transit, which in turn can affect the absorption of certain drugs. Oral solutions are rarely likely to fall short of bioequivalence relative to solid oral formulations, although during the development of a ranitidine effervescent oral solution dosage form containing sodium acid pyrophosphate (SAPP), a marked decrease in absorption was observed in the extent of ranitidine absorption from the liquid formulation relative to the conventional oral tablet. The formulation contained 150 mg ranitidine with 1132 mg SAPP together with 1.5 MBq hndium chloride solutions. Small intestinal transit time was decreased to 56% in the presence of the excipient. The rapid small intestinal transit associated with an excipient of a solution dosage form resulted in a decreased extent of ranitidine absorption. " ... 

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