Effect on lipid peroxidation

Nihro, Y., Miyataka, H., Sudo, T., Matsumoto, H. and Satoh, T. (1991). 3-O-Alkylascorbic acids as free radical quenchers synthesis and inhibitory activity effect on lipid peroxidation. J. Med. Chem. 34, 2152-2157. 

Nerudova J, Gut I, Savolainen H. 1988. Consequences of acrylonitrile metabolism in rat hepatocytes Effects on lipid peroxidation and viability of the cells. Environ Res 46 133-141. 

It is of interest that under certain conditions SOD can manifest both inhibitory and stimulatory effects on lipid peroxidation. Thus, Nelson et al. [37] showed that small SOD concentrations (up to 5 pg ml ) were protective in the reoxygenated isolated myocardium but very high doses (50 pg ml ) exacerbated the injury. These authors hypothesized that superoxide may not only initiate lipid peroxidation but also inhibited it, reacting with free radicals ... 

As mentioned earlier, when NO concentration exceeds that of superoxide, nitric oxide mostly exhibits an inhibitory effect on lipid peroxidation, reacting with lipid peroxyl radicals. These reactions are now well studied [42-44]. The simplest suggestion could be the participation of NO in termination reaction with peroxyl radicals. However, it was found that NO reacts with at least two radicals during inhibition of lipid peroxidation [50]. On these grounds it was proposed that LOONO, a product of the NO recombination with peroxyl radical LOO is rapidly decomposed to LO and N02 and the second NO reacts with LO to form nitroso ester of fatty acid (Reaction (7), Figure 25.1). Alkoxyl radical LO may be transformed into a nitro epoxy compound after rearrangement (Reaction (8)). In addition, LOONO may be hydrolyzed to form fatty acid hydroperoxide (Reaction (6)). Various nitrated lipids can also be formed in the reactions of peroxynitrite and other NO metabolites. 

Viarengo, A., L. Canesi, M. Pertica, G. Poli, M.N. Moore, and M. Orunesu. 1990. Heavy metal effects on lipid peroxidation in the tissues of Mytilus galloprovincialis Lam. Comp. Biochem. Physiol. 97C 37-42. 

A series of substituted diaryselenides were examined in three lipid peroxidation model systems isolated rat liver microsomes treated with Fe(II)/(ADP)/ascorbate and isolated rat hepatocytes treated with two different initiators of oxidation. In rat hepatocytes, all of the tellurides performed more effectively than the selenides. Particularly for the rat liver microsome system, the substituent effects on lipid peroxidation were consistent with what would be expected Electron-donating groups give more active compounds, while electron-withdrawing groups give poorer antioxidants. The same trends were seen for substituted diaryItellurides in inhibition of linoleic acid peroxidation in a two-phase model, where the dimethylamino... 

Dlugosz A, Sawicka E, Marchewka Z. Styrene and ethylene glycol have a synergistic effect on lipid peroxidation that is better protected than repaired byCoQlO. Toxicol in Vitro 2005 19(5) 5818. 

Laughton, M. J., Halliwell, B., Evans, P. J., and Hoult, J. R. (1989). Antioxidant and prooxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. Biochem. Pharmacol. 38, 2859-2865. 

Wu, S.Y. and Brewer, M.S., Soy protein isolate antioxidant effect on lipid peroxidation of ground beef and microsomal lipids, J. Food Sci., 59, 702, 1994. 

Inhibitory effect on lipid peroxidation in rat liver microsomes... 

Wuweizisu B from Schisandra chinensis showed strong protective effects on lipid peroxidation damage to the surface of cultured hepatocytes of rats treated with Fe2+/cystein and also scavenger free radical properties [240], On the other hand, the oral administration of wuweizisu B increases the activities of antioxidant enzymes. 

OKUDA, T., KIMURA, Y., YOSHIDA, T., HATANO, T., OKUDA, H., ARICHI, S., Studies on the activities of tannins and related compounds from medicinal plants and drugs. 1. Inhibitory effects on lipid peroxidation in mitochondria and microsomes of liver, Chem. Pharm. Bull, 1983, 31, 1625-1631. 

In rat hepatocytes, the compound curcumin was cyto-protective at concentrations of 0.05 mM, whereas at 5 mM the observed protective effect on lipid peroxidation was accompanied with a tendency to increase cellular glutathione depletion and lactate dehydrogenase leakage (Donatus et al. 1990). 

Choi. J.H.. and Byun, D.S. (1989) Physiological Activity of to3 Polyunsaturated Fatty Acids of Dark-Fleshed Fish. II. An-tioxidative Effect on Lipid Peroxidation in Rats, Han guk Susan Hakhoechi 22,109-114. 

Ugartondo, V., Mitjans, M., Vinardell, M.P. Applicabilitz of lignins from different sources as antioxidants based on the protective effects on lipid peroxidation induced bz oxzgen radicals. Ind. Crops Prod. 30, 184—187 (2009)... 

Liu, M., R. Wallin, A. Wallmon et al. Mixed tocopherols have a stronger inhibitory effect on lipid peroxidation than alpha-tocopherol alone.. 7 Cardiovasc Pharmacol 39(5), 2002 714-21. 

The incorporation of LA and CLA isomers into cellular phospholipids has different effects on lipid peroxidation measured as oxygen consumption (Fig. 10.8—10.11). PC(SA LA) at a level of 5 mol% of total fatty acids reduced oxygen consumption in all of the tested PC liposome systems (Fig. 10.8—10.11), while 5 mol% PC(SA c9,rl 1-CLA) increased oxygen consumption in liposomes prepared with PC(soy) and PC(egg yolk), but reduced it in PC(rat heart) and PC(rat brain) liposomes. These data indicated that PC(SA cS,tl 1-CLA) may exhibit antioxidant or pro-oxidant properties in different phospholipids systems including membranes. Interestingly, PC(SA rlO,differed from both PC(SA LA) and PC(SA c9,t 1-CLA) in its influence on lipid peroxidation in liposome prepared with different PC. Incorporation of 5 mol% PC(SA rlO,cl2-CLA) decreased lipid oxidation in the soy PC liposomes (Fig. 10.8), but increased lipid oxidation in the liposomes prepared from all the other PC, egg, rat heart, and rat brain (Fig. 10.9—10.11). 

MRF A is an antioxidant and a potent inhibitor of lipid peroxidation [66-68]. MRF A showed inhibitory activity on NADPH-dependent lipid peroxidation (1C50 = 2.8 mcM) in rat hver microsomes, being 30 times and 70 times stronger than alpha-tocopherol (1C50 = 87 mcM) and ascorbic acid (1C50 = 200 mcM), respectively. Indole (1C50 = 330 mcM) and tryptamine (1C50 = 260 mcM), the partial stmctures of MRF A, had much weaker effects on lipid peroxidation [67]... 

Ferulic acid has antiallergic, broad cardiovascular, and hematologic effects (antiplatelet aggregation, antithrombic, etc.) as well as inhibitory effects on lipid peroxidation (see angelica) ... 

Hydroxy 1,4-dimethyl carbazoie has a pronounced inhibitory effect on lipid peroxidation 109). Inhibition of resorption in organ culture of fetal rat long bones was found using carbazoie-1-carboxylic acid as a test material 103). 

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