Effect on hematological parameters

Reductions of approximately 10% in total hemoglobin and mean cell hemoglobin were observed in rats receiving 1,000 mg/kg/day of MIL-H-83282LT for 4 weeks (Mattie et al. 1993). A 47% increase in white blood cell counts was also observed in this study. No effects on hematological parameters were seen in rats similarly exposed to MIL-H-83282 (Mattie et al. 1993). 

NMRI male mice exposed to benzene at concentrations ranging from 1 to 200 ppm, exhibited a reduction in bone marrow cellularity (nucleated cells per tibia), a reduction in the number of colony-forming granulopoietic stem cells (CFU-C) per tibia, and an increase in frequency of micronucleated polychromatic erythrocytes (MN-PCE) that varied with dose and duration of exposure as explained below (Toft et al. 1982). Mice exposed continually (24 hours/day) to 21 ppm or more benzene in air for 4-10 days showed significant changes in all of the parameters. No adverse effects on hematological parameters were noted in mice exposed to 14 ppm benzene continuously for 1-8 weeks (Toft et al. 1982). 

In other intermediate-duration exposure studies, inhalation exposures to uranium dioxide dusts containing 1 mg U/m for 30 weeks and 2 mg U/m for 26 weeks in rabbits and guinea pigs, respectively (Stokinger et al. 1953), 19.4 mg U/m for 5 weeks in mice, and 9.2 mg U/m for 5 weeks in dogs and rats had no adverse effects on hematological parameters (Rothstein 1949b). Similarly, exposures to... 

The effects of 1,4-dichlorobenzene ingestion on hematological parameters reported in both human and animal studies indicate that this is an area of potential concern for humans exposed to 1,4-dichlorobenzene. Possible effects in humans have been associated with red blood cells anomalies. Because of sex and species differences seen in animal studies (i.e., effects on red blood cells in rats and effects on... 

No adverse effects on hematological, biochemical, or electrocardiographic parameters were observed. Mild gastrointestinal disturbances, which subsided spontaneously without the need for stopping treatment, were reported in two volunteers at the 300 mg dose and in one volunteer at the 450 mg dose (Pravina et al. 2007). 

Golbs S, Fuchs V, Leipner E, et al. 1978b. [Studies into effects of pesticide combinations on laboratory rats. 2nd communication Studies into action on selected hematological parameters and blood glucose]. Arch Exp Vet Med Leipzig 32. (German)... 

Siddiqui MKJ, Rahman MF, Anjum F, et al. 1987b. Effect of oral administration of endosulfan on some hematological parameters and serum enzymes in rats. Pesticides 21 25-27. 

The 1-h no-observed-effect level (NOEL) of 5 ppm represented a no-effect exposure level for mice, and 11 ppm represented a lowest-observed-adverse-effect level (LOAEL) based upon altered hematologic parameters in mice that were reversible at 5 d post-exposure. At 15 ppm, the effects on hematocrit levels, packed cell volume, and RBC count were more severe but were approaching reversibility at 11 d. The use of what might appear to be a conservative NOEL in the derivation of AEGL-2 is justified by the documented latency in the expression of severe toxicity in humans even after removal from exposure... 

There were no effects on the red blood cell counts of dogs exposed to 0, 15, 48, or 260 ppm hexachloroethane for 6 weeks (Weeks et al. 1979). Although other hematological parameters were apparently determined, the red cell count was the only parameter that was specified. Accordingly, it is not possible to speculate whether inhalation exposure to hexachloroethane has any effect on other hematological parameters. 

The photodynamic effect on red blood cells of the /xara-tetraglucosyl-porphyrin 31a and its analogous with the sugar unit in orto position has also been analysed. Considering the possibility of the photosensitiser causing hemolysis, this study became crucial.29 The two symmetric derivatives have proved to be ineffective in these cells. However, the asymmetric derivatives 49B and 50B are phototoxic and changes in hematological parameters were observed.29... 

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