Dyslipoproteinemia

Relevant Lipoproteins from Patients with Dyslipoproteinemia. 136... 

Monogenic dyslipoproteinemias can generally be grouped into five categories (1) hypertriglyceridemia with an increase in chylomicrons and the clinical sign of pancreatitis, (2) mixed hyperlipidemia with an increase in chylomicron and VLDL remnants and an increased risk of premature atherosclerosis, (3) hypercholesterolemia with an increase in LDL and an increased risk for premature atherosclerosis, (4) hypoalphalipoproteinemia with low HLD and an increased risk for premature atherosclerosis, and (5) hypolipoproteinemia with a decrease in VLDL and LDL, which may lead to neurological disease. 

C4. Carlson, L. A., and Philipson, B., Fish-eye disease. A new familial condition with massive corneal opacities and dyslipoproteinemia. Lancet 1, 921-924 (1979). 

V3. Van Biervliet, J. P., Vinaimont, N., Caster, H, Rossenue, M., and Belpaire, F., A screening procedure for dyslipoproteinemia in newborns. Apoprotein quantitation on dried-blood spots. Clin. Chim. Acta 120, 191-200 (1982). 

Dyslipoproteinemia is diagnosed in most patients using plasma lipid and lipoprotein cholesterol concentrations. Dyslipoproteinemias have previously been defined in terms of arbitrarily defined cut points for lipids and lipoprotein, but are now based on the relationship between fipoprotein levels and the risk for CHD (see discussion later in this chapter). 

Bachorik PS, Rifkind BM, Kwiterovich PO. Lipids and dyslipoproteinemia. In Henry JB, ed. Clinical Diagnosis and Management by Laboratory Methods, Vol. 19th ed. Philadelphia W.B. Saunders, 1996 208-36. 

Kwiterovich PO, Jr. Diagnosis and management of familial dyslipoproteinemia in children and adolescents. Pediatr Cfin North Am 1990 37 1489-523. 

LaRosa JC, Chambless LE, Criqui MH, Frantz ID, Glueck CJ, Heiss G, Morrison JA. Patterns of dyslipoproteinemia in selected North American populations. The Lipid Research Cfinics Program Prevalence Study. Circulation 1986 73 112-29. 

Lees RS, Wilson DE, Schonfeld G, Fleet S. The familial dyslipoproteinemias. Prog Med Genet 1973 9 237-90. 

Other studies of H NMR spectra of blood plasma in cancer have included general studies, comparison of NMR and chromatographic methods, testicular cancer, effects on plasma sialic acids, use of both H and C NMR spectra, lung cancer, the effect of trauma and dyslipoproteinemia. ... 

Dowite, N.T., Copperman, N., Leicht, T., Kwong, T., and Jacobson, M.S. (1995) Effects of Dietary Modification and Fish Oil Supplementation on Dyslipoproteinemia in Pediatric Systemic Lupus Erythematosus,/. Jf/ienmatol. 22,1347-1351. 

Dyslipoproteinemias are characterized by distinct profiles of Apo B-containing lipoprotein particles. 

LP-X and Other Abnormal Lipoprotein Particles in Secondary Dyslipoproteinemia... 

Parra H, Fievet C, Boniface B, Bertrand M, Moschetto J, Fruchart JC (1984) Lipoproteins, apolipoproteins and coronary artery disease assessed by coronary arteriography. In De Gennes JL et al. (eds) Latent and dyslipoproteinemias and atherosclerosis. Raven, New York, pp 87-197... 

Pomrehn P, Duncan B, Weissfeld L, Wallace RB, Barnes R, Heiss G, et al. The associationof dyslipoproteinemias with symptoms and signs of peripheral arterial disease. The Lipid Research Clinics Program Prevalence Study. Circulation 1986 73 1100-1107. 

For each of these categories of dyslipoproteinemias, there are currently two established genetic causes. This chapter will focus on the appropriate diagnosis of these genetic dyslipoproteinemias. 

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