Dynamin

The force-producing MAPs (kinesin, dynein, and dynamin) function as energy-transducing ATPases to provide the motive force for cilia and flagella by means of... 

Bohn LM, Belcheva MM, Coscia CJ (2000) p-opioid agonist inhibition of kappa-opioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. J Neurochem 74 574-581... 

Cvejic et al. [133] and Trapaidze et al. [134] have reported that the C-terminus of the 8 receptor is essential for the internalization and downregulation of the receptors. Truncation of the 8 receptor attenuates receptor internalization. Residue Thr353 seems to be selectively involved in the internalization of the receptor, since mutation of this amino acid blocks the internalization process. Recent studies by Chu et al. [135] not only confirm the role of the C-terminus in internalizing the 8 receptor but have shown that clathrin-coated pits are involved in the internalization since a K44I mutant of dynamin I blocks the rapid internalization of the 8 receptor. These studies have identified a structural basis for the differential regulation of the three opiate receptors. 

Other pinocytotic pathways also exist that do not depend on either caveolae or clathrin, although these are not as well defined [55]. Specific receptors continue to be internalized in the absence of clathrin or caveolin and these pathways can be monitored by following glycosyl phos-phatidylinositol (GPI (-anchored proteins. Nonclathrin, noncaveolin pathways may also be responsible for the reuptake of membrane in neuroendocrine cells after stimulated secretion. Some, but not all, of these pathways appear to require dynamin. 

CaMKI and CaMKII) Dynamin-1 GTPase required for endocytosis that is phosphorylated by protein kinase C and dephosphorylated by calcineurin upon membrane depolarization and binds to AP2. Important for budding and fusion pore closure. 

Praefcke, G. J. and McMahon, H. T. The dynamin superfamily universal membrane tubulation and fission molecules Nat. Rev. Mol. Cell Biol. 5 133-147, 2004. 

Growth-Arrest-Specific protein 2 Domain Gastrin/cholecystokinin/caerulein family Dynamin GTPase effector domain Gelsolin homology domain G protein y subunit-like motifs Glycoprotein hormone a chain homologs... 

Surger, K.N., Demel, R.A., Schmid, S.L. and de Kruijff, S., 2000, Dynamin is membrane-active lipid insertion is induced by phosphoinositides and phosphatidic acid. 

Schmid, S.L., McNiven, M.A. and De CamilU, P., 1998, Dynamin and its partners a progress report. Curr. Opin. Cell Biol, 10 504-512. 

Hinshaw JE. Dynamin and its role in membrane fission. Annu Rev Cell Dev Biol 2000 16 483-519. 

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