Dynamin domains

Growth-Arrest-Specific protein 2 Domain Gastrin/cholecystokinin/caerulein family Dynamin GTPase effector domain Gelsolin homology domain G protein y subunit-like motifs Glycoprotein hormone a chain homologs... 

Damke, H., Binns, D. D., Ueda, H., Schmid, S. L., and Baba, T. (2001) Dynamin GTPase domain mutants block endocytic vesicle formation at morphologically distinct stages. Mol Biol Cell 12,2578-2589. 

The pleckstrin-homology domain is named after pleckstrin, where it was found first (pleckstrin is a major platelet protein which is a substrate of protein kinase Pleckstrin and brain spectrin contain two domains, 2 about 120 residues each, with similar sequences in their amino- and carboxy-terminal parts. To date, at least 90 such PH-domain sequences have been described in proteins with very diverse functions, such as spectrin,43 cytosolic protein kinases, phospholipase C isoforms (PLC-P, -y, and the GTPase dynamin,44.45 guanine nucleotide exchange factors for monomeric GTP-bind-ing proteins, the GTPase-acdvating protein for Ras, the Ras-GAP, and cytoskeletal and several other proteins. 

D. Timm, K. Salim, I Gout, 1— Guruprasad, M. Waterfield, and T. Blundell. Crystal structure of the pleckstrin homology domain from dynamin. Nature Struct Biol, 1 (11), 782 788, 1994. 

Dynamin is a microtubule-associated GTP-binding protein. Dynamins are activated by proteinkinase C. They have a PH, a pleckstrin-homology domain and bind inositol phospholipids which aaivate the GTPase of dynamin. Dynamins are involved in microtubule assembly and vesicular traffic. 

Shupliakov O, Low P Grabs D, Gad H, Chen H, David C, Takei K, De Camilli P, Brodin L (1997a) Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions. Science 276 259-263. 

This value refers to the affinity of the SH3 domain for the entire proline-rich region of dynamin. 

Dong, J., Misselwitz, R., Welfle, H., and Westermann, P. (2000). Expression and purification of dynamin II domains and initial studies on structure and function. Protein Expr. Purif. 20, 314-323. 

Grabs, D., Slepnev, V I., Songyang, Z., David, G., Lynch, M., Cantley, L. C., and De Camilli, P. (1997). The SHS domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SHS binding consensus sequence. /. Biol. Chem. 272, 13419-13425. 

Vidal, M., Goudreau, N., Cornille, E, Cussac, D., Gincel, E., and Garbay, C. (1999). Molecular and cellular analysis of Grb2 SH3 domain mutants Interaction with Sos and dynamin.y. Mol. Biol. 290, 717-730. 

Okamoto, P. M., Herskovits, J. S., and Vallee, R. B. (1997). Role of the basic, proline-rich region of dynamin in Sre homology 3 domain binding and endocytosis. J. Biol. Chem. 272, 11629-11635. 

Dynamin 1, a member of the dynamin family of large GTPases. Mammalian dynamin 1 forms ring-like assemblies aroimd the necks of budding synaptic vesicles. StmeturaUy, it can be subdivided into five domains. The high-resolution X-ray structure of the GTPase domain from Rattus norvegicus was described in 2005 [K. Takei et al.. Nature 1995, 374,186 ... 

Skare P, Kreivi JP, Bergstrom A, Karlsson R (2003) Profilin I colocalizes with speckles and Cajal bodies a possible role in pre-mRNA splicing. Exp Cell Res 286 12-21 Solomaha E, Szeto FL, Yousef MA, Palfrey HC (2005) Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins specificity, occlusion, and the effects of phosphorylation. J Biol Chem 280 23147-23156... 

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