Dynamic Force Spectroscopy

361-366, (k) Yokoyama, T. Yokoyama, S. Kamikado, T. Okuno, Y. Mashiko, 

11 ISHiKAWA, Y. Ohiea, a. Sakata, M. Hieayama, C. Kunitake, M. Chem. Commun. 2002, 2652-2653. 

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Gotsmann B, Anczykowski B, Seidel C and Fuchs H 1999 Determination of tip-sample interaction forces from measured dynamic force spectroscopy curves Appl. Surf. Sc/. 140 314... 

Odorico, M., Teulon, J.-M., Bessou, T., Vidaud, C., Bellanger, L., Chen, S.-W., Qucmcncur, fi., Parot, P., and Pellequer, J.-L. (2007) Energy landscape of chelated uranyl Antibody interactions by dynamic force spectroscopy. Biophys. J. 93, 645-654. 

Dynamic Force Spectroscopy A Fokker-Planck Approach. 

R. Merkel, P. Nassoy, A. Leung, K. Ritchie, and E. Evans Energy Landscapes of Receptor-Ligand Bonds Explored with Dynamic Force Spectroscopy. Nature 397, 50 (1999). 

Zapotoczny S, Auletta T, de Jong MR, Schonherr H, Huskens J, van Veggel FCJM, Reinhoudt DN, Vancso GJ. Chain length and concentration dependence of p-cyclodextrin-ferrocene host-guest complex rupture forces probed by dynamic force spectroscopy. Langmuir 2002 18 6988-6994. 

E. Evans and P. Williams, Dynamic force spectroscopy, in Physics of Bomolecules and Cells, Vol. LXXV (H. Flyvbjerg, F. Jillicher, P. Ormos, and F. David, eds.) Springer-Verlag, Berlin, 2002, pp. 145-204. 

Keywords Atomic Force Microscopy (AFM), Dynamic Force Spectroscopy (DFS), Unfolding... 

Janshoff A, Steinem C (2001a) Energy lndscapes of ligand-receptor couples probed by dynamic force spectroscopy. Chem Phys Chem 2 577-579... 

Evstigneev M, Reimann P (2003) Dynamic force spectroscopy Optimized data analysis. Phys. Rev. E 68 045103 ... 

Raible M, Evstigneev M, Reimann P, Bartels FW, Ros R (2004) Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complex. J. Biotech. 112 13-23... 

In AFM single molecule dynamic force spectroscopy (AFM-FS), binding forces between two molecules of interest are measured by functionally immobilizing them on two different surfaces (i.e. the tip of an AFM and an appropriate counter surface) that are brought in mechanical contact under physiological conditions (see Figure 2). 

Merkel, R., Nassoy, P., Leung, A., Ritchie, K. and Evans, E. (1999) Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy. Nature 597, 50-53. 

Commentary on Energy landscapes of biomolecular adhesion and receptor anchoring at interfaces explored with dynamics force spectroscopy, E. Evans, Faraday Discuss., 1998, 111, 1. 

One of the most promising developments has been that of dynamic force spectroscopy, a technique whose development began less than ten years ago. A founding figure of the field. Professor Evan Evans of the Universities of British Columbia and Boston, gave the first comprehensive account of the technique in a Faraday Discussion organised by the Biophysical Chemistry Group of the Faraday Division in 1998. " ... 

Force measurements made under these conditions are commonly referred to as dynamic force spectroscopy (DFS). The advantage with DFS measurements is that it is possible to assess values to physical entities that cannot be addressed by measurements under steady-state conditions, predominantly those related to the transition state, i.e., Axat and Ajab [12,46,47]. 

E. Evans, Looking inside molecular bonds at biological interfaces with dynamic force spectroscopy. Biophys. Chem. 82, 83-97 (1999)... 

Dynamic force spectroscopy (DFS) was introduced [1] allowing us to understand quantitatively dissipative and non-dissipative processes in dynamic force microscopy [2]. Using a combined experimental and computer simulation technique it is possible to reconstruct force/distance ciuves without using any model potentials and parameters. This method opens the perspective to extract material parameters such as atomic densities of the surface investigated as well as local elastic properties... 

Watabe, H., Nakajima, K., Sakai, Y, and Nishi, T., Dynamic force spectroscopy on a single polymer chain, Macromolecules, 39, 5921-5925 (2006). 

Without the need to stretch the elastic sensing element, a robust device could be constructed that would be deployable for use in the field. One design of the sensing element for such a device is shown in Figure 9.57. Vlado Hlady has built a measuring device capable of what he calls dynamic force spectroscopy, and we look forward to future opportunities to develop a range of useful nanosensors capable of the ultimate in sensitivity that would be useful in medical diagnostics and in detection of terrorist threats. 

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