Epithelium duodenal

Flemstrom, G. Garner, A. (1984). Some characteristics of duodenal epithelium. In Mucus and mucosa, ed. J. C. Nugent M. O Connor, pp. 94-108. Ciba Foundation Symposium, no. 109. Pitman London. 

The esophageal epithelium appears more susceptible to acid damage than either the gastric or duodenal epithelium, and the explanation for this is found in the structural and secretory properties of the squamous lining of the esophagus adjacent to the stomach. 

Helicobacter pylori to human gastric epithelium.26 Clinical studies have identified H. pylori as a causative agent in gastric and duodenal ulcers.27 Considerable evidence exists to suggest that carbohydrate-based treatments could be an effective means to combat infection.28 Since bacterial attachment is a prerequisite to infection,29 soluble Leb oligosaccharides may serve as therapeutic alternatives to broad-spectrum antibiotics. 

The l,25(OH)2D3-stimulated transport of calcium across the intestinal epithelium has been extensively studied in our laboratory. l,25(OH)2D3 can stimulate rapid transport of calcium in vascularly perfused chick duodenal loops [19] before the ap-... 

Peptic ulcer disease is associated with Helicobacter pylori infection in 90% of patients with gastric and duodenal ulceration. Elimination of H. pylori infection with antibiotics heals the peptic ulcer and the associated symptoms. Combination therapy with antibiotics, anti-secretory agents, namely H2-receptor antagonists or proton pump inhibitors, and bismuth salts has significantly improved the clinical outcome of peptic ulcer disease. Not all strains of H. pylori cause peptic ulcer disease, and other factors are necessary for H. pylori colonization and disease to occur. Flagellated motile bacteria resist peristalsis and adhere to gastric epithelium in a highly specific manner. 

Calcium is absorbed in the whole small intestine with the bulk preferentially from duodenum and the upper part of jejunum. The absorption consists of a passive diffusion as well as an active transport through the mucosa. A schematic description of the cellular and paracellular pathway for calcium absorption from the intestinal lumen to blood across the intestinal epithelium can be seen in Fig. 1. The higher rate of calcium transport in duodenum as compared to that in jejunum and ileum is probably not due to greater cellularity of duodenum but to a greater calcium transport by each duodenal cell. The molecular basis for calcium entry across the brushborder is not known in detail, but initial calcium binding may be an early step in the activation of a calcium channel or to increase membrane fluidity [3]. 

Chapter 5 Regulation of Growth of Gastric Epithelium Section 5 Gastric and Duodenal Ulcer Disease Chapter 1 History... 

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