Dubos, Rene

Dubos, Rene. Louis Pasteur Free Lance of Science (Little Brown, Boston, 1950). Fischer, Emil. Bedeutung der Stereochemie fur die Physiologie. Z. Physiol. Chem. 26, 60-87 (1898). 

David, Edward E., Jr., 2,169 de Nevers, Noel, 168 Diamandis, Peter, 196 Diamond, Malcolm, 110 Diebold, John, 51 Dorf, Richard C., 60, 168 Drucker, Peter, 42, 62 Dubbury, John, 95 Dubos, Rene, 6, 42, 47 DuBridge, Lee, 53, 174... 

Only One Earth Barbara Ward and Rene Dubos... 

Hans Zinsser, Resistance to Infectious Disease, The Macmillan Co., New York, N.Y., 1931. See also Rene J. Dubos, Biochemical Determinants of Microbial Diseases, Harvard University Monograph in Medicine and Public Health, No. 13, Cambridge, Mass., 1954. 

In 1939, Rene Dubos, Waksman s former postdoctoral student, extracted two chemicals, tyrocidine and gramicidin, from the soil germ Bacillus brevis. These chemicals cured bacterial infections in cattle but were too toxic for humans. This discovery prompted a number of scientists to expand the search for microbes in the soil, microbes capable of making chemicals that could kill disease-causing bacteria in humans. 

It should be pointed out that the approaches outlined here are certainly not new, especially to microbiologists. In the 1947 book, The Bacterial Cell 38 Rene Dubos includes a chapter on the variability of bacteria, in which he points out that bacteria also exhibit orderly, predictable changes which are related to the age of the culture and which are the expression of a definite growth cycle. It seems likely that he was on the right track however, it is difficult to reproduce his experiments because the cultures were not deposited or classified. 

Some distinguished investigators are less than optimistic about our ability to control unwanted effects arising from our technological tools. Rene Dubos is quoted as follows (13) ... 

Not that there hadn t been any grand claims. Like other men, Rene J. Dubos once said, scientists become deaf and blind to any argument or evidence that does not fit into the thought pattern which circumstances have led them to follow. And so along with the welter of experiment and observation came a few flutters of higher Tc and some enormous rushes to judgment. Most of the results, however, were transient and nonreproducible—or just false. 

I selected ribonuclease A in part because it was a Rockefeller enzyme. First of all, the activity of this enzyme was discovered here at Rockefeller University by Rene Dubos. Then Moses Kunitz isolated and crystallized... 

The 1930s were also the period for a new era, the birth of antibiotic treatments. Rene Dubos (Figure 1.16) had been recruited by Oswald Avery, to the Rockefeller Institute... 

Over time, some bacteria have developed ways to circumvent the effects of antibiotics. Rene Dubos had the foresight... 

Stefansson, V. 1960. Cancer Disease of Civilization An Anthropological and Historical Study, with an introduction by Rene Dubos. New York HUl and Wang. 

Virchow never deviated from the concept of disease as phenomenon, independent of its etiology or explanation. The secret of disease, concluded medical popularizer Rene Dubos, appeared to reside in the anatomy of the tissues. It was not only the secret of disease that resided there, its definition did as well. 

The fact that 20-50 percent of the bacteria in soil are effective in destroying a variety of microorganisms, including other bacteria, has been known for many decades. In 1939 this prompted Rene Dubos (1901-82), at the Rockefeller Institute for Medical Research, to examine one such bacterium. Bacillus brevis, firom which he isolated a chemical component, tyrothricin, capable of destroying bacteria. The cyclic decapeptide gramicidin S, sequenced by Martin and Synge, is derived from tyrothricin. 

Department of Imaging and Interventional Radiology, Centre Hospitaller Rene Dubos, 6 Avenue de Tile de France, 95303 Cergy-Pontoise, France J. Golzarian, MD... 

At the United Nations Conference on the Human Environment (Stockholm, 1972), Rene Dubos, advisor to the conference, authored the now popular maxim Think Globally, Act Locally. It is solutions at a local level that can help resolve the global environmental concerns faced by all of us today. 

Rene Dubos. Brainy Quotes available at http //www.brainyquote. com/quotes/authors/r/rene dubos.html (accessed June 12, 2009). 

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