Dual-chamber syringe delivery system

Dual-chamber syringe. For delivery of two established vaccines (e.g., polyribosyl ribitol phosphate conjugated to tetanus toxoid and diphtheria-tetanus-whole cell pertussis and inactivated poliovirus vaccine) at the same time, a dual-chamber syringe delivery system can be used. The proximal chamber may contain a vaccine in the freeze-dried solid state, and the distal chamber contains a vaccine in the liquid formulation that allows reconstitution of the vaccine in the proximal chamber. The immune response by the dualchamber delivery of vaccination was equivalent to that by the separate-injection method of vaccination. The dual-chamber syringe can be used for safe and effective delivery of two different vaccines that are not yet available as a single formulation for pediatric applications. ... 

FIGURE 26.5 (See color insert following page 40). Cnrrent and future trends in delivery systems for mAbs inclnde (a) dual-chamber cartridge and prefilled syringe with attached needle (conrtesy Vetter), (b) pen systems for self-administration, and (c, d) needle-free injection systems (BioJect). 

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