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Drugs timolol maleate

Hiratani and Alvarez-Lorenzo prepared imprinted CLs made of HEMA or A, A-diethylacrylamide (DEAA), low cross-linker proportions, and a small proportion of functional monomer (methacrylic add, MAA), which was able to interact with drug (timolol maleate) via ionic and hydrogen bonds. It was found that imprinted HEMA-based and DEAA-based CLs took up more timolol than the... [Pg.1191]

Co-administration of ofloxacin and chitosan in eyedrops increased the bioavailabUity of the antibiotic [290]. Trimethyl chitosan was more effective because of its solubility (plain chitosan precipitates at the pH of the tear fluid). On the other hand, N-carboxymethyl chitosan did not enhance the corneal permeability nevertheless it mediated zero-order ofloxacin absorption, leading to a time-constant effective antibiotic concentration [291]. Also W,0-carboxymethyl chitosan is suitable as an excipient in ophthalmic formulations to improve the retention and the bioavailability of drugs such as pilocarpine, timolol maleate, neomycin sulfate, and ephedrine. Most of the drugs are sensitive to pH, and the composition should have an acidic pH, to enhance stability of the drug. The delivery should be made through an anion exchange resin that adjusts the pH at around 7 [292]. Chitosan solutions do not lend themselves to thermal sterilization. A chitosan suspension, however. [Pg.190]

The aim of this study was to find out whether it is possible to affect the dissolution of monoisopropyl ester of PVM-MA and drug release form the polymer in vivo in tear fluid by adding basic salts to the matrices. Timolol maleate was used as the drug. [Pg.156]

Aggarwal, D., and Kaur, I. P. (2005), Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system, Int. I. Pharm., 290(1-2), 155-159. [Pg.761]

An 80-year-old woman with gastrointestinal bleeding had a sinus bradycardia (52/minute) despite acute blood loss. The only drug she had used that was an AV nodal depressant was timolol maleate 0.5%, one drop to both eyes every day. Continuous electrocardiography showed transient complete AV block without ventricular escape for nearly 6 seconds about 1 hour after instillation of timolol eye drops. She also reported having previously had episodes of dizziness and occasional falls 1-2 hours after instillation of her eye drops. [Pg.3428]

Soni S, Jain SK, Jain NK. Effect of penetration enhancers on transdermal delivery of timolol maleate. Drug Dev Ind Pharm 1992 18(10) 1127-1135. [Pg.251]

If a patient with bronchial hyperreactivity requires /3-blocker therapy, one of the selective /3i-blockers (e.g., acehutolol, atenolol, metoprolol, or pindolol) should be used at the lowest possible dose. Celiprolol and betaxolol appear to possess greater cardioselectiv-ity than currently marketed drugs. " Fatal status asthmaticus has occurred with the topical administration of the nonselective timolol maleate ophthalmic solution for the treatment of open-angle glaucoma. Early investigations with ophthalmic hetaxolol suggest that it is well tolerated even in timolol-sensitive asthmatics. - ... [Pg.580]

In contrast to the LLC phases of GMO and (EO) -O-alkyl surfactants, only a handful of reports on the study of LLC phases of ionic surfactants for drug delivery are available. For example, the L, Qn, and Hu phases of the wa-ter/octanol/dioctyl sodium sulfosuccinate system have been studied for the transport of water and glucose across human skin [ 149]. Also, Qii phases of mixed ionic and uncharged phospholipids in water have been explored for the sustained in vitro release of timolol maleate, a drug for treatment of glaucoma [150]. [Pg.211]

The synthesis of polyacrylic acid nanoparticles from inverse microemulsions has also been described in the literature. Polyacrylic acid is a well-known bioadhesive agent. Hence, polyacrylic acid nanoparticles loaded with the drug would have enhanced bioavailability and controlled release characteristics. The synthesis of timolol maleate and bri-monidine nanoparticles for improved ocular and oral delivery has been reported [153, 154]. [Pg.291]

De, T.K. and Hoffman, A.S. (2001) A reverse microemulsion polymerization method for preparation of bioadhesive polyacrylic acid nanoparticles for mucosal drug deliv. Loading and release of Timolol Maleate. Art. Cells, Blood Subst. Immob. Biotech., 29, 31-46. [Pg.300]

Fig. 9. Release rate of timolol maleate from a 7 3 blend of polymers prepared from 3,9-bis (ethylidene-2,4,8,10-tetraoxaspiro [5,5] undecane) and 1,6-hexanediol and 3,9-bis (ethylidene-2.4,8,10-tetraoxaspiro 5,5] undecane and rrans-cyclohexanedimethanol at pH 7.4 and 37 °C. Drug loading 2 wt% [31]. Reprinted with permission... Fig. 9. Release rate of timolol maleate from a 7 3 blend of polymers prepared from 3,9-bis (ethylidene-2,4,8,10-tetraoxaspiro [5,5] undecane) and 1,6-hexanediol and 3,9-bis (ethylidene-2.4,8,10-tetraoxaspiro 5,5] undecane and rrans-cyclohexanedimethanol at pH 7.4 and 37 °C. Drug loading 2 wt% [31]. Reprinted with permission...
S. A. Agnihotri, T.M. Aminabhavi, Chitosan nanoparticles for prolonged delivery of timolol maleate. Drug Development and Industrial Pharmacy 33 (2007) 1254—1262. [Pg.311]

Hydrogels Timolol maleate Ocular retention and sustained drug delivery [91]... [Pg.41]

In a recent study carried out in the laboratory of the present author,30 the effect of different agents, known for their capacity of altering the permeability of biological membranes, was tested on in vitro permeation through rabbit corneas of three ophthalmic drugs possessing different lipophilic character timolol maleate (TM), levobunolol hydrochloride (LB) and cyclopentolate hydrochloride (CY). (Octanol/water distribution coefficients = 0.051,0.197 and 0.247, respectively). [Pg.118]

New efforts were directed to use this material in novel ophthalmic drug delivery platforms recent reports in scientific literature propose the SH as solid bio-adhesivedrug delivery system. Crosslinked SH films loaded with timolol maleate were successfully used to reduce intra ocular pressure in normotensive rabbits, prolonging the hypotensive effect for longer than commercial timolol maleate eye drops [35]. [Pg.155]


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See also in sourсe #XX -- [ Pg.81 ]




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