Drugs mercury

Thiols have a marked ten dency to bond to mercury and the word mercaptan comes from the Latin mer curium captans which means seizing mercury The drug dimercaprol is used to treat mercury and lead poisoning It IS 2 3 dimercapto 1 propanol... 

Mercuri, NB, Bond, A and Bemardi, G (1997) Electrophysiological pharmacology of the autoreceptor mediated responses of dopaminergic cells to antiparkinsonian drugs. Trends Pharmacol. Sci. 18 232-235. 

With the advent of mercury intrusion porosimeters, it is advantageous to perform a pore size distribution of investigational batches of a drug [43]. The Washburn equation [44] states that the pressure, P, necessary to intrude a pore is given by... 

Until now there has been no effective technology for reducing groundwater mercury to two parts per billion, as required by the maximum contamination limit for drinking water established by the U.S. Food and Drug Administration and the U.S. EPA. 

Cyanides, including metal-cyanide complexes Drug residues Chromium, cadmium, lead, mercury, nickel. dissolve material used in sealing a site... 

Mishra and Gode developed a direct current polarographic method for the quantitative determination of niclosamide in tablets using individually three different buffer systems, namely Mcllraine s buffers (pH 2.20 8.00), borate buffers (pH 7.80—10.00), and Britton Robinson s buffers (pH 2.00—12.00) as well as 0.2 M sodium hydroxide. The drug was extracted from the sample with methanol, appropriate buffer was added to an aliquot and the solution then polarographed at the dropping-mercury electrode versus saturated calomel electrode at 25°C [36], The resultant two-step reduction waves observed were irreversible and diffusion-controlled. For the quantitative determination, the method of standard addition was used. Niclosamide can be determined up to a level of 5—10 pg/mL. 

Lopez-Fonseca et al. [11] discussed the theory of reverse pulse polarography and the technique was applied in the determination of penicillamine electrochemically coated on a dropping-mercury electrode. Using long drop times and short pulses, the drug can be determined at levels as low as 50 nM in the presence of Cu(II), and the technique compares well with normal-pulse and differential-pulse polarography. 

The hypotensive and sedative drug reserpine (256) has long been known to decompose in daylight. The photolysis has been studied in aqueous solution under a mercury discharge tube [ 159] and in chloroform at 360-370 nm [ 160]. The conclusions were essentially the same. The derivatives detected were isoreserpine (the C-3 epimer of reserpine), 3,4-dehydroreserpine (257) and lumireserpine which was shown to be 3,4,5,6-tetradehydroreserpine (258). 

Irradiation of an alcoholic solution of the antitubercular drug isoniazid (261) with a low-pressure mercury lamp by Ninomiya and Yamamoto gave isolated yields of the hydrazone (262, 60%) and the hydrazide (264, 17%). Nicotinic and picolinic acid hydrazides reacted similarly, as did other alcohols. The production of (262) was easily understood since it was known that photolysis of ethanol gave acetaldehyde which would react spontaneously with the... 

Wechsler, J. (2001). Clinical trial safety and oversight top policy agenda. Appl. Clinical Trials, January 2001, pp. 18-21. www.actmagazine.com/articles/act/act0101 jill.pdf Willman, D. (2000). Quickened pace of drug approvals by FDA taking toll. San Jose Mercury News, Dec. 28, 2000. 

The adsorption behavior of the psychotropic drug flunitrazepam (256) at the hanging mercury drop electrode was studied by staircase voltammetry and by adsorptive stripping differential pulse voltammetry. 256 can be determined down to nanomolar levels by using adsorptive preconcentration prior to the differential pulse voltammetry scan. The method was applied to determination of 256 in human urine530. 

---