Drugs image analysis

Each of the aforementioned techniques is capable of measuring powder that would be used in low-dose, solid oral dosage formulations. The technique must be compatible with the drug substance, and must be capable of producing the information that is needed. For example, if the particle size distribution is needed to ensure dose content uniformity, photon correlation spectroscopy can only provide an average particle size. In this instance, laser diffraction or image analysis would be more suitable techniques. Table 13.1 contains a comparison of the techniques that have been discussed. 

Rainsford (1987) published an assay for gastro-ulcerogenic activity of non-steroidal anti-inflammatory drugs in cholinomimetic-treated mice using visual image analysis. 

Davies, M. C., Brown, A., Newton, J. M., et al. SSIMS and SIMS imaging analysis of a drug delivery system. Surface Interface Anal. 11 591-595,1988. 

The results presented here show some interesting image analysis parameters that can be used for the morphological study in the CNS after drugs or toxicants exposure (see, for example, refs. 3, 4, and 25). In our experience these parameters (area, relative area, ROD, etc.) were extremely useful for the study of the effects of canabimimetic drugs on the young rat s CNS. 

Trask OJ Jr, Moore A, LeCluyse EL (2014) A micropattemed hepatocyte coculture model for assessment of hver toxicity using high-content imaging analysis. Assay Drug Dev Technol 12,16-27. 

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