Drug packaging materials metal

Some antioxidants possess antimicrobial properties, such as propyl gallate and butylated hydroxy anisole, which are somewhat effective against bacteria. Butylated hydroxy toluene has demonstrated some antiviral activity. Compatibility of antioxidants with the drug, packaging system and the body should be studied carefully. For example, tocopherols may be absorbed onto plastics ascorbic acid is incompatible with alkalis, heavy metals, and oxidizing materials such as phenylephrine, and sodium nitrite and propyl gallate forms complexes with metal ions such as sodium, potassium and iron. 

Secondary packaging components are not intended to make contact with the dosage form. Examples are cartons, which are generally constructed of paper or plastic, and overwraps, fabricated from a single layer of plastic or from a laminate made of metal foil, plastic, and/or paper. In special cases, secondary packaging components provide some additional measure of protection to the drug product. In such cases it could be considered a potential source of contamination and the safety of the raw materials should be taken into consideration. 

Containers used for topical administration include plastics, glass, and metals. Most topical preparations are packaged in plastic jars, metal tubes, glass jars or, in some cases, a combination of these materials. Suitable tests are performed to ensure that drug products do not leach or react with the proposed containers. The various types of topical formulations are discussed in Pharmaceutical Dosage Forms (1151) of the USP/NFP ... 

In many cases the metal sheets must be coated before they are formed into containers. This demands extremely high flexibility of the cross-linked paint system. However, the coating material must also be extremely resistant to the container contents, must not discolor, and must, at least in the food-packaging sector, satisfy relevant legal provisions for example the Food and Drug Administrations in the USA and the... 

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