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Drug-induced immune hemolytic anemia

Garratty G, Petz LD. Drug-induced immune hemolytic anemia. Am J Med 1975 58(3) 398 07. [Pg.498]

Arndt PA, Garratty G. The changing spectrum of drug-induced immune hemolytic anemia. Semin Hematol. 2005 42(3) 137-144. [Pg.242]

The severity of drug-induced immune hemolytic anemia is usually a function of the rate of hemolysis. Hemolytic anemia caused by drugs via the hapten/adsorption and autoimmune mechanisms tend to be slower in onset and mild to moderate in severity. Conversely, hemolysis prompted via the neoantigen mechanism (innocent bystander) phenomenon may have a sudden onset, lead to severe hemolysis, and result in renal failure. The treatment of drug-induced immune hemolytic anemia includes the removal of the offending agent and supportive care. Glucocorticoids are usually unnecessary, and practitioners have questioned their efficacy. ... [Pg.1883]

Garratty G. Review Drug induced immune hemolytic anemia—the last decade. Immu-nohematology 2004 20(3) 138-146. [Pg.65]

Johnson ST, Eueger JT, Gottschall JL. One center s experience the serology and drugs associated with drug-induced immune hemolytic anemia—a new paradigm.Transfusion 2007 47(34) 697-702. [Pg.65]

DIHA Drug-induced immune hemolytic anemia... [Pg.58]

Examples of type II cytotoxic antibody-mediated drug reactions include drug-induced immune hemolytic anemia, drug-induced thrombocytopenia where a number of different mechanisms are involved and acute agranulocytosis in which more than 70 % of cases are caused by drugs... [Pg.89]

Eckrich RJ, Fox S, Mallory D. Cefotetan-induced immune hemolytic anemia due to the drug-adsorption mechanism. Immunohematol 1994 10(2) 51-4. [Pg.697]

The mechanisms that have been proposed to explain how drugs can induce immune hemolytic anemia are similar to the mechanisms that produce drug-induced agranulocytosis. The first mechanism is the adsorption of the drug to the RBC membrane to form a hapten. [Pg.1881]

Kim S, Song KS, Kim HO, Lee HM. Ceftriaxone-induced immune hemolytic anemia detection of drug-dependent antibody by ex-vivo antigen in urine. Yonsei Med J 2002 43(3) 391. ... [Pg.503]

Besides this hapten or penicillin-type of drug-induced hemolysis, a second less frequent mechanism, the so-called innocent bystander mechanism can occur (46,49,50). Penicillin-antibody complexes are only loosely bound to erythrocytes and activate complement, which can be detected on the erythrocyte surface with the complement antiglobulin test ( complement or nongamma type). This mechanism plays a part in immune hemolytic anemias due to various drugs other than penicillins. The hemolytic reaction can continue for weeks after withdrawal of penicillin, that is as long as sufficient penicillin-coated erythrocytes and specific antibodies remain in circulation. [Pg.2758]

Christie DJ, Mullen PC, Aster RH (1985) Fab-mediated binding of drug-dependent antibodies to platelets in quinidine- and quinine-induced thrombocytopenia. J Clin Invest 75 310-314 Cunha PD, Lord RS, Johnson ST, Wilker PR, Aster RH, Bougie DW (2000) Immune hemolytic anemia caused by sensitivity to a metabolite of etodolac, a nonsteroidal anti-inflammatory drag. Transfusion 40 663-668... [Pg.75]

The answer is a. (Katzung, p 162.) Many drugs can cause an immunohemolytic anemia. Methyldopa may cause a positive Coombs test in as many as 20% of patients, along with hemolytic anemia. Other drugs with similar actions on red blood cells are penicillins, quinidine, procainamide, and sulfonamides. These form a stable or unstable hapten on the red cell surface, which induces an immune reaction I immunoglobulin G (IgG) antibodies] and leads to dissolution of the membrane. [Pg.122]

In contrast to a-methyldopa-induced hemolytic anemia, most drug-induced hemolytic anemia, especially for penicillins [34] and cephalosporins [35], involves drug-dependent antibodies, presumably because the drug acts as a hapten to directly modify erythrocytes or form immune complexes [36], However, there are many examples where a drug, such as nomifensine, induces both drug- (or metabolite)-dependent and drug-... [Pg.457]

Worlledge SM. Immune drug-induced hemolytic anemias. Semin Hematol 1973 10(4) 327-44. [Pg.498]

Autoimmune hemolytic anemia has rarely been reported with the older cephalosporins, including cefalexin (40), cefalotin (41,42), cefazolin (43), and cefaloridine (44). The main laboratory findings correspond to the drug adsorption mechanism classically found in benzylpenicil-lin-induced immune hemolysis. Antibodies cross-reacting with cefalotin and benzylpenicillin were found in both benzylpenicillin-induced and cefalotin-induced hemolysis (43,45) Cases have also been reported with cefamandole (46), cefalexin (47), ceftriaxone (48), cefotaxime (49,50), cefotetan (51,52) and ceftazidime (53). [Pg.690]

SPECIFIC DRUG-INDUCED IMMUNOTOXICITY IMMUNE-MEDIATED HEMOLYTIC ANEMIA... [Pg.58]

See other pages where Drug-induced immune hemolytic anemia is mentioned: [Pg.590]    [Pg.1877]    [Pg.1881]    [Pg.1881]    [Pg.1881]    [Pg.1882]    [Pg.59]    [Pg.61]    [Pg.172]    [Pg.590]    [Pg.1877]    [Pg.1881]    [Pg.1881]    [Pg.1881]    [Pg.1882]    [Pg.59]    [Pg.61]    [Pg.172]    [Pg.1883]    [Pg.74]    [Pg.75]    [Pg.24]    [Pg.371]    [Pg.1882]    [Pg.7]    [Pg.58]    [Pg.70]    [Pg.486]    [Pg.37]    [Pg.306]    [Pg.455]    [Pg.1358]    [Pg.3041]    [Pg.138]    [Pg.244]    [Pg.58]    [Pg.60]    [Pg.380]   


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