Drug development pipelines

Pharmaceutical companies usually have multiple compoxmds in various stages of the pipeline, with specific metrics aroxmd expected stage completion. The staging of compounds within the drug development pipeline is important for a few reasons ... 

Figure 3.1 Hypothetical drug development pipeline, illustrating activities during a 12-month period. Three stages of drug development are indicated at the bottom of the figure. The corresponding milestones for each stage are indicated at the top of the figure. (Courtesy of Milestone Development Services, Newtown, Pa., USA.)...

A qualitative process approach to accelerated development emphasizes the elimination of drug candidates from the pipeline. This approach targets the advanced evaluation of specific pharmaceutical properties. The reward is not necessarily intuitive introduce a qualitative process change earlier in the drug development pipeline, resulting in the proactive identification of promising lead compounds and the utilization of fewer resources during the costly clinical development phases. This approach is driven by kinetic ... 

Almost 35% of all compounds in the drug development pipeline fail because of improper ADME behavior and toxicity. Thus in silico models and algorithms addressing bioavailability, phase I and phase II metabolism, blood-... 

One first needs to stress that risk-taking is inherent to pharmaceutical discovery and therefore one often need to take conscious risks when one selects a development candidate. Although challenging compounds have been successfully developed (with massive investments in technical R D) in the past (cyclosporine, tamoxifen, amiodarone. .. ), the question is how many of these difficult compounds one can afford in a drug development pipeline For one successful compound, how many did fail despite significant (or sometimes desperate) efforts From our experience in the past few years a few points emerge ... 

The tools covered in this section can be used to predict structural or functional motifs and secondary structure. Predicting target structure is critical in advancing candidate compounds (new chemical entities) in the drug-development pipeline. 

For example, the application of HTS technology on the large libraries generated by CC methods was expected to inundate drug development pipelines with structurally innovative compounds [26]. However, after 12 years of utilizing these methods, these expectations have clearly not been... 

An increase in protein drug candidates within drug development pipelines combined with an increase in the use of protein biomarkers for decision making... 

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