Drug, drugs pipeline

Incyte. Incyte s Product Pipeline at Incyte Pharmaceuticals/Pflzer. Available at http //www.incyte.eom/drugs product pipeline.html chemokine. 

Lehman Brothers, The fruits of genomics drug pipelines face indigestion until the new biology ripens. New York, January, 2001. 

Pharmaceutical companies usually have multiple compoxmds in various stages of the pipeline, with specific metrics aroxmd expected stage completion. The staging of compounds within the drug development pipeline is important for a few reasons ... 

Burton, T., By learning from failures, Lilly keeps drug pipeline full. Wall Street., April 21,2004. 

Pharmaceutical firms have to reexamine their strategies to devise means to increase their drug pipelines for continuous streams of products. The high failure rates of Investigational New Drugs during clinical trials (see Exhibit 5.8) necessitate the development of better assay systems and animal models that correlate closely with human pharmacodynamics and pharmacokinetics. The study of pharmacogenomics will be crucial to address this issue. 

By definition, pay-as-you-go plans permit sponsors to implement different incentives at multiple points along the drug discovery pipeline. As seen below, these can be either push or pull incentives. By contrast, end-to-end systems establish just one incentive for the entire process. In practice, no... 

Chiral amines are valuable synthons that dominate agrochemicals and pharmaceutical drug pipelines. Current methods for the preparation of amines are largely based upon resolution, and this is an excellent example of an industrial success. BASF makes a range of chiral amines by acylating racemic amines with proprietary esters, whereby one enantiomer is acylated to the amide, which can be easily separated from the unreacted amine [7]. For example, the resolution of racemic 15 in... 

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