Drug delivery system chitosan

They are also used for biomedical applications (biomedical devices, and drug delivery systems). Chitosan and its derivatives form air permeable films. This property facilitates cell regeneration when the films are used to protect tissues against microbiological attack. For this reason chitin and chitosan are also good candidates for artificial skin, and biodegradable sutures. Producers of ehitine and chitosan will not be presented here because there are 63 main companies 30 are located in Asia, 14 in the USA, 12 in Europe, 6 in Canada, and one in Russia. 

Wu J, Wei W, Wang LY, Su ZG, Ma GH (2007) A thermosensitive hydrogel based on quatemized chitosan and polyethylene glycol) for nasal drug delivery system. Biomaterials 28 2220-2232. 

Aiedeh, K., and Taha, M.O., Synthesis of chitosan succinate and chitosan phthalate and their evaluation as suggested matrices in orall administered, colon-specific drug delivery systems, Arch. Pharm (Weinheim), 332 103-107 (1999). 

Solid dispersions have been explored as drug delivery systems for over 30 years, initially starting with various forms of polyethylene glycols, citric and succinic acids, and sugars. However, more recent success has been achieved using hydroxypropy-lcellulose (HPC), ethylcellulose (EC), and the commercial forms of methylacrylic acids and their copolymers sold under the name Eudragits. In addition, chitosans have been evaluated for this purpose. 

Bernkop-Schnurch, A., D. Guggi, and Y. Pinter. 2004. Thiolated chitosans development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. J Control Release 94 177. 

De Campos, A.M., et al. 2004. Chitosan nanoparticles as new ocular drug delivery systems In vitro stability, in vivo fate, and cellular toxicity. Pharm Res 21 803. 

Ilium, L., N.F. Farraj, and S.S. Davis. 1994. Chitosan as a novel nasal drug delivery system for peptide drugs. Pharm Res 11 1186. 

Some naturally occurring polymers have been reported to exhibit efflux pump modulating properties. For example, a drug delivery system based on chitosan has been shown to nearly double the oral bioavailability of the P-glycoprotein substrate rhodamine 123 in vivo in rats in comparison with buffer control (Foger et al. 2006c). 

Pan Y, Li YJ, Zhao HY, Zheng JM, Xu H, Wei G, Hao JS, Cui FD (2002) Bioadhesive polysaccharide in protein delivery system chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 249(1-2) 139-147 Park K, Robinson JR (1984) Bioadhesive polymers as platforms for oral-controlled drug delivery method to study bioadhesion. Int J Pharm 19 107-127 Patel H, Ryman BE (1981) Systemic and oral administration of liposomes. In Knight CG(ed) Liposomes From Physical Structure To Therapeutic Applications, Elsevier, Amsterdam, pp 409-441... 

Porter CJH, Charman WN (1997) Uptake of drugs into the intestinal lymphatics after oral administration. Adv Drug Del Rev 25(1) 71—89 Prabaharan M, Mano JF (2004) Chitosan-based particles as controlled drug delivery systems. Drug Delivery 12(l) 41-57... 

Chitosan and hydroxypropylchitosan were found to be enzymatically degraded so that they can be used for implantable controlled-release dosage forms. Due to the moieties of chitosan (i.e., amine and hydroxyl groups), chitosan can be cross-linked or complexed with citric acid, EDTA, or glutaraldehyde, and the cross-linked or complexed chitosans have been applied to drug delivery systems. 

The procedure for the preparation of cross-linked chitosan microspheres coated with polysaccharide or lipid for intelligent drug delivery systems is illustrated in Fig. 11 [230]. 

Enriquez de Salamanca, A., Diebold, Y., Calonge, M., Garcia-Vazquez, C., Callejo, S., Vila, A., and Alonso, M. J. (2006), Chitosan nanoparticles as a potential drug delivery system for the ocular surface Toxicity, uptake mechanism and in vivo tolerance, Invest. Ophthalmol. Vis. Sci., 47(4), 1416-1425. 

Thacharodi, D. Rao, K.P. Development and in vitro evaluation of chitosan-based transdermal drug delivery systems for the controlled delivery of propranolol hydrochloride. Biomaterials 1995, 16, 145-148. 

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