Drug delivery screening

Antibody interaction drug delivery, 9 64 Antibody purification, 14 145 Antibody recognition, recombinant phage screening by, 12 506-507 Anticakes, for sodium nitrite, 22 857 Anticaking agents, 12 31, 63... 

Foster KA, Avery ML, Yazdanian M, Audus KL (2000) Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery. Exp Cell Res 243 359-366. 

The large gap between pre-clinical and clinical research can be (at least partly) bridged by screening of the disposition properties as well as the efficacy of drug delivery preparations in (diseased) human tissues in vitro... 

Early development of polymers in injectable drug delivery primarily involved PLA and poly(lactic-co-glycolic) acid (PLGA) due to the prior use of these polymers in biomedical applications as sutures. Besides the safe and biocompatible nature of these polymers, their ease of availability made them ideal first candidates for screening parenteral CR formulations. Some of the early biodegradable polymer-based products for injectable sustained release used these polymers. However because... 

HIV spreads by contact with body fluids, and the common modes of infection include sexual intercourse and contaminated needles used for intravenous drug delivery. Previously, therapeutic use of infected blood and infected breast milk for the baby were also modes of transmission but both have declined due to better screening for blood and AIDS education of expectant mothers. The virus is carried in infected CD4+ T cells, macrophages or as free viruses in blood, semen, vaginal fluids and milk. 

The rational development of a drug delivery system can be timely and costly. Formulation development and optimization requires a step-wise approach by Lrst screening and evaluating various formulationsin vitro before one initiates formulations/dosage forms tesfringvo. 

Key Words Gene therapy Drug delivery Polymers Transfection High-throughput screening. 

Phillips RM, Pearce J, Loadman PM et al. Angiogenesis in the hollow fiber tumor model influences drug delivery to tumor cells Implications for anticancer drug screening programs. Cancer Res 1998 58 5263-6. 

Because poor bioavailability represents one of the principal causes of compound failure, absorption and metabolism assays feature prominently in lead optimization screens. As oral administration represents the ideal route of drug delivery, models that predict low absorption across the gastrointestinal (GI) tract are commonly employed. Caco-2 cell assays have been... 

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