Drug Delivery Applied for Wound Dressings

For a wound to be healed, it has to be fed by either using the body s own resources, which in many cases are inadequate because of vascular damage, or by using supplements, which may be applied directly at the site of the wound, rather than rely on supplementation that is dependent on the circulation. Supplements like vitamins A, C and E, as well as zinc and copper are important in the wound healing process. 

Zinc is the most essential trace element to the healing process being involved in epidermal cell division and in the transcription of RNA for the production of cell 

The application of collagen to topical drug delivery has been relatively limited for growth factors, but much more success has been in its application as a vehicle for topical antimicrobial compounds [129]. A widespread application of the antimicrobial agents is used on the open burn wound surface and other extreme trauma. They can substantially reduce and prevent the microbial biobru-den load and risk of infection/ reinfection and colonization of bacteria which interfere with wound healing processes by inducing an inflammatory host response [130,131] (Table 13.2). 

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