Bioactive drug delivery

Wang [3] prepared the amphiphilic biocompatible cyclodextrin graft polymer, poly(ethylene glycol-g-cyclodextrin), (III), containing modified cyclodextrin which was used as a bioactive drug delivery agent. 

Pitt, C. G., Marks, T. A., and Schindler, A., Biodegradable drug delivery systems based on aliphatic polyesters application to contraceptives and narcotic antagonists, in Controlled Release of Bioactive Materials (R. Baker, ed.). Academic Press, New York, 1980, pp. 19-43. 

Kohn, J., and Langer, R., Non-peptide poly(amino acids) for biodegradable drug delivery systems, in Proceedings of the 12th International Symposium on Controlled Release of Bioactive Materials (N. A. Peppas and R. J. Haluska, eds.). Controlled Release Society, Lincolnshire, IL, 1985, pp. 51-52. 

Transferosomes represent another system of encapsulation using ultradeformable vesicle carriers for bioactive molecules, applied until now for direct transdermal drug delivery. They are built from polar lipids and have high flexibility, and are rich in unsaturated fatty acids and carotenoid pigments." ... 

Although the drug delivery to the lipid bilayer membrane is just the first step for bioactivities and phopholipid vesicles are rather simple in view of the composite structure of biomembranes, the unambiguous specification of the preferential location of the drug is essential the successive processes of the action are expected to be induced via the delivery site in membranes. We expect more advances in the dynamic NMR study, so that we can get insight into the mechanism of DD in membranes. 

Ordered mesoporous silica have already been studied as carriers for drug delivery [1,2] recently, their use has also been proposed in bone tissue engineering [3,4], in combination with bioactive glass-ceramic scaffolds [5,6]. The kinetics of ibuprofen release in SBF [7] from MCM-41 silica with similar pore diameter has shown puzzling discontinuities [3,6,8] aim of the present work is to assess whether these anomalies may be related to structural changes in the MCM-41 mesoporous spheres under the adopted conditions. 

As above reported, among microparticles, CLS have been proposed as a new type of fat-based encapsulation system developed for drug delivery of bioactive compounds. 

Some active materials are carriers for drugs (drug delivery systems), some have immobilized peptides to enable cell adhesion or migration, some are degradable by hydrolysis or by specific enzyme action. Some contain bioactive agents (e.g., heparin, thrombomodulin) to prevent coagulation or platelet activation while others incorporate bioactive groups to enhance osteo-conduction. Many include polyethylene oxide to retard protein adsorption and this is perhaps the closest we have come to a kind of inertness. 

Ultimately, for Pt(IV) anticancer drugs, a combination of incorporation of bioactive ligands that specifically target cancer cells, control over ligand-exchange kinetics, and selective activation by light would allow for temporal and spatial control of drug delivery and activation. 

Binodal curves, 20 320-321 Bins concept, 70 32 Bioaccumulation, of herbicides, 73 310 Bioactive barrier, defined, 3 758t Bioactive fixation, 72 611 Bioactive food ingredients, 7 7 646 Bioactive nutritions, 7 7 645t Bioactive substances identifying, 77 646 safety of, 77 647 Bioactive zone, defined, 3 758t Bioadhesive agents, 9 48, 49 Bioadhesive drug delivery systems, 9 45... 

In an earlier investigation by the authors (1) biodegradable poly(ester-amides) were prepared and used as drug delivery devices for internally administered bioactive agents. Unsaturated analogs, (II), were prepared by Chu et al. (2). 

The above described pressure sensitive adhesive compositions are especially suitable for assisting in delivering a bioactive agent, such as a drug to a bioactive-agent-accepting substrate, i.e., the patient s skin. The pressure sensitive adhesive composition may be employed in three modes of bioactive agent delivery (83). 

Lambert T Dev V Rechavia E, Forrester J, Litvak p Eigler N. Localized arterial wall drug delivery from a polymer-coated removable metallic stent kinetics, distribution, and bioactivity offorskolin. Circulation 1994 90 1003-101 I. 

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