Dose-response with organ systems

MULTIPLE CHEMICAL SENSITIVITY An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to many chemically-unrelated compounds at doses far below those established in the general population to cause harmful effects. No single widely accepted test of physiologic function can be shown to coiTelate with symptoms. 

The TGD (EC 2003), Chapter 3.9, addresses repeated dose toxicity and provides guidance on data requirements, evaluation of data, and dose-response assessment. Included is a section on specific system/organ toxicity dealing with guidance on investigation of neurotoxicity (Section 4.7.7.3) and... 

The most commonly accepted definition of MCS was written by Mark Cullen, M.D., a professor of medicine and epidemiology at Yale University. In Workers With Multiple Chemical Sensitivities, Occupational Medicine 2 (1987) 655-626, he writes, Multiple chemical sensitivities is an acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses far below those established in the general population to cause harmful elfects. No single widely accepted test of physiologic function can be shown to correlate with symptoms. ... 

Since acute radiation toxicity responses become apparent shortly after exposme, history is an important criterion in determining whether the radiation is related to the cause of a particular complication or adverse effect. As with any attempt to specify a dose-response relationship, the dose is an important component. In contrast, late radiation toxicity in organs such as the kidneys, fiver, or central nervous system (CNS) will not be seen until months or perhaps even years after radiation exposure (Center for Drug Evaluation, 2005). The integrated response is often to the radiation response and attempts to heal any radiation damage that has been caused. 

In order for healthcare providers to triage chemically exposed casualties effectively and appropriately, they must be provided with accurate and timely information about the chemical release. This information should include a description of the chemical of concern including synonyms, physical properties, and applicable exposure standards. In addition, healthcare providers will need pertinent toxicological information on the potential routes of exposure involved, target organ systems, dose-response relationships, potential exposure sequelae, the risk, if any, of secondary exposure to healthcare staff and facilities, and recommended medical procedures to be followed for exposed individuals. 

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