Dosages General index

In 113 patients undergoing general anesthesia, intravenous midazolam 15 mg slowed recovery of the twitch height after vecuronium and atracurium compared with diazepam. The recovery index was not altered (162). However, in another study in 20 patients, midazolam 0.3 mg/kg did not affect the duration of blockade, recovery time, intensity of fasciculations, or adequacy of relaxation for tracheal intubation produced by suxamethonium 1 mg/kg, nor the duration of blockade and adequacy of relaxation for tracheal intubation produced by pancuronium 0.025 mg/kg in incremental doses until 99% depression of muscle-twitch tension was obtained (161). Furthermore, in 60 patients undergoing maintenance anesthesia randomly assigned to one of six regimens (etomidate, fentanyl, midazolam, propofol, thiopental plus nitrous oxide, or isoflurane plus nitrous oxide), midazolam did not alter rocuronium dosage requirements (165). 

All of the monographs in the Handbook are thoroughly cross-referenced and indexed so that excipients may be identified by either a chemical, a nonproprietary, or a trade name. Most monographs list related substances to help the formulator to develop a list of possible materials for use in a new dosage form or product. Related substances are not directly substitutable for each other but, in general, they are excipients that have been used for similar purposes in various dosage forms. 

Byron PR, et al. Recommendations of the USP advisory panel on aerosols on the USP general chapters on aerosols [601] and uniformity of dosage units [905]. Pharm Forum 1994 7 7477-7503. http //www.fda.gov/cder/guidance/index.htm. 

Treatment with theophyUine requires consideration of its interpatient variability in dose requirements, the relationship between efficacy and toxicity vs. serum concentration, and its narrow therapeutic index. Thus, therapeutic drug monitoring is generally applied for dosing individualization, using theophyUine serum concentration measurements and simultaneous clinical assessments as guiding tools for dosage adjustments. 

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