DNA damage carcinogenesis

Smith PJ (1984) Relationship between a chromatin anomaly in ataxia telangiectasia ceUsand enhanced sensitivity to DNA damage. Carcinogenesis 5 1345-1350... 

Graziewicz, M., Wink, D.A., Laval, F. (1996). Nitric oxide inhibits DNA ligase activity. Potential mechanisms for NO mediated DNA damage. Carcinogenesis 17, 2501-2505. 

WEI H, CAO Q AND RAHN R o (1996) Inhibition of UV light- and Fenton reaction-induced oxidative DNA damage by the soybean isoflavone genistein. Carcinogenesis. 17 (1) 73-7. 

Loft, S., Vistisen, K., Ewertz, M., Tjonneland, A., Overvad, K. and Poulsen, H.E. (1992). Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans influence of smoking, gender and body mass index. Carcinogenesis 13, 2441-2447. 

Oikawa, S. Hirosawa, I. Hirakawa, K. Kawanishi, S. Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol. Carcinogenesis 2001, 22, 1239-1245. 

Gradelet, S., Le Bon, A.M., Berges, R., Suschetet, M., and Astorg, P. 1998. Dietary carotenoids inhibit aflatoxin Bl-induced liver preneoplastic foci and DNA damage in the rat Role of the modulation of aflatoxin B1 metabolism. Carcinogenesis 19 403—411. 

Verhagen H, Poulsen HE, Loft S, Van-Poppel G, Willems MI and Van-Bladeren PJ. 1995. Reduction of oxidative DNA-damage in humans by Brussels sprouts. Carcinogenesis 16(4) 969—970. 

Matsui, M. et al., The role of oxidative DNA damage in human arsenic carcinogenesis Detection of 8-hydroxy-2 -deoxyguanosine in arsenic-related Bowen s disease, J. Invest. Dermatol., 113, 26, 1999. 

Lee YJ, Park SJ, Ciccone SL, Kim CR, Lee SH (2006) An in vivo analysis of MMC-induced DNA damage and its repair. Carcinogenesis 27(3) 446-453 Loehrer PJ, Einhom LH (1984) Drugs five years later. Cisplatin. Ann Intern Med 100(5) 704-713 Li G, Widom J (2004) Nucleosomes facilitate their own invasion. Nat Struct Mol Biol 11 763-769 Liu W, Sun D, Hurley LH (2005) Binding of G-quadruplex interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaca cells. Nucleosides Nucleotides Nucleic Acids 24(10-12) 1801-1815... 

B. Glinghammar, H. Inoue and J. J. Rafter, Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1, Carcinogenesis, 2002, 23(5), 839. 

Many sites of exposure to bile in the body are associated with the development of cancer, e.g. the oesophagus, gallbladder and bile duct, pancreas, small intestine and colon (reviewed in ref. 2). One explanation for increased cancer at these sites could be that bile acids stimulate carcinogenesis via DNA-damaging effects. This chapter provides an overview of research conducted in relation to establishing the genotoxic and carcinogenic effects of bile acids. 

Weber E, Bannasch P Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine. Carcinogenesis 15 1235-42, 1994 Robbiano L, Mereto E, Corbu C, et ah DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells. Mutat Res 368(l) 41-7, 1996... 

Parker RJ, Gill I, Tarone R, et al. Platinum-DNA damage in leukocyte DNA of patients receiving carboplatin and cisplatin chemotherapy measured by atomic absorption spectrometry. Carcinogenesis 1991 12 1253-1258. 

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