Diuretics, pharmaceutical industry

The separation of enantiomers is a very important topic to the pharmaceutical industry. It is well recognized that the biological activities and bioavailabilities of enantiomers often differ [1]. To further complicate matters, the pharmacokinetic profile of the racemate is often not just the sum of the profiles of the individual enantiomers. In many cases, one enantiomer has the desired pharmacological activity, whereas the other enantiomer may be responsible for undesirable side-effects. What often gets lost however is the fact that, in some cases, one enantiomer may be inert and, in many cases, both enantiomers may have therapeutic value, though not for the same disease state. It is also possible for one enantiomer to mediate the harmful effects of the other enantiomer. For instance, in the case of indacrinone, one enantiomer is a diuretic but causes uric acid retention, whereas the other enantiomer causes uric acid elimination. Thus, administration of a mixture of enantiomers, although not necessarily racemic, may have therapeutic value. 

Microencapsulated solid preparations are widely used in pharmaceutical, chemical, and other industries to protect various substances from environmental impact, as well as for extending their action [137], In the pharmaceutical field, in particular, these preparations are mainly used to get controlled release drug kinetics, to minimize side effects, to reduce gastric irritations, and to mask the unpleasant taste of the contained drug [137-142]. Indeed, many different active components are microencapsulated analgesics, antibiotics, antihistamine, cardiovascular agents, iron salts, antipsychot-ics [143], vitamins, peptides [144], proteins [145], antiasthma [140,146], broncodilators, diuretics, anticancerogens, tranquilizers, and antihypertensives [137],... 

Uses Fertilizer animal feed supplement stabilizer for resins, plastics, explosives softener for cellulose in paper industry deodorizer penetrant cure accelerator and activator airport runway deicing agent dispersant (animal glue, proteins) plasticizer for starch adhesives food additive, yeast nutrient, fermentation aid flour treatment agent diuretic, antiseptic in pharmaceuticals antistat, humectant in cosmetics keratin softenerfor dry skin prods. in ammoniated dentifrices in side seam cements for food-contact containers... 

Besides their application in the food industry, polyols are employed in the pharmaceutical and chemical industries and in medicine as a potent osmotic diuretic (Monedero et al. 2010 Saha and Racine 2010 Ortiz et al. 2013). In this respect, mannitol is applied to patients with kidney failure, brain edema, and intraocular pressure (von Weymarn et al. 2002). 

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