Disopyramide drug interactions

Drug Interactions Other antihypertensive agents Carbamazepine (vasodilators, ACE inhibitors, Rifampin diuretics, and beta-blockers) Phenobarbital Digoxin Cyclosporine Disopyramide Theophylline Flecainide Inhalation anesthetics Quinidine Neuromuscular blocking agents Cimetidine Lithium ... 

Teichman SL, Fisher ID, Matos JA, Kim SG. Disopyramide-pyridostigmine report of a beneficial drug interaction. J Cardiovasc Pharmacol 1985 7(1) 108-13. 

Barletta MA, Eisen H. Isosorbide dinitrate-disopyramide phosphate interaction. Drug Intell Chn Pharm 1985 I9(I0) 764. 

Another potential for drug interaction of roxithromycin may involve changes in binding of drugs to plasma proteins [26, 39]. In in vitro binding experiments, Zini et al. [26] found that disopyramide displaced roxithromycin and increased the free concentration of roxithromycin. The magnitude of the increase was not reported. Similar results were not seen with lidocaine or prednisolone [26]. Thus, the clinical significance of this interaction is unknown. 

In patients receiving antidiabetic drugs, start with the lowest dose of disopyramide if there is no alternative. Measure creatinine clearance. If creatinine clearance is 40 mL/min or less, the dose of disopyramide should not exceed 100 mg and should be administered once daily if creatinine clearance is <15 ml/min. Watch for and warn patients about symptoms of hypoglycaemia For signs and symptoms of hypoglycaemia, see Clinical Features of Some Adverse Drug Interactions, Hypoglycaemia... 

D. Important drug interactions may result in toxicity. Hypotension is more likely to occur in patients taking beta blockers, nitrates, or both, especially if they are hypovolemic after diuretic therapy. Patients taking disopyramide or other... 

Choudhury L, Grais Ih4 Passman RS. Torsade de pointes due to drug interaction between disopyramide and claritiiromycin. HeartDis 999) 1, 206-7. 

Other drugs that may interact with cardiac glycosides include the following Albuterol, amphotericin B, beta-blockers, calcium, disopyramide, loop diuretics, nondepolarizing muscle relaxants, potassium-sparing diuretics, succinylcholine, sympathomimetics, thiazide diuretics, thioamines, and thyroid hormones. 

Drugs that may affect amiodarone include hydantoins, cholestyramine, fluoroquinolones, rifamycins, ritonavir, and cimetidine. Drugs that may be affected by amiodarone include anticoagulants, beta-blockers, calcium channel blockers, cyclosporine, dextromethorphan, digoxin, disopyramide, fentanyl, flecainide, hydantoins, lidocaine, methotrexate, procainamide, quinidine, and theophylline. Drug/Lab test interactions Amiodarone alters the results of thyroid function tests, causing an increase in serum T4 and serum reverse T3 levels and a decline in... 

The interaction between proteins and a drug is governed by the law of mass action, in that the proportion of bound drug remains constant, provided the binding sites are not saturated. With the possible exception of valproic acid and disopyramide, the saturability of binding sites does not occur within therapeutic ranges. 

Interactions. Erythromycin and the other macro-lides are enzyme inhibitors and interfere with the metabolic inactivation of some drugs, e.g. warfarin, carbamazepine, theophylline, disopyramide, increasing their effects. Reduced inactivation of terfena-dine may lead to serious cardiac arrhythmias, and of ergot alkaloids may cause ergotism. 

Pharmacodynamic interactions. Many TCAs cause sedation and therefore co-prescription with other sedative agents such as opioid analgesics, antihistamines, anxiolytics, hypnotics and alcohol may lead to excessive drowsiness and daytime somnolence. The majority of TCAs can have undesirable cardiovascular effects, in particular prolongation of the QT interval. A similar risk of QT prolongation arises with many other cardiovascular drugs including amiodarone, disopyramide, procainamide, propa-... 

H. Takahashi, H. Ogata, and Y. Seki, Binding interaction between enantiomers of disopyramide and mono-N-dealkyldisopyramide on plasma protein, Drug Melab. Dispos., 19 554 (1991). 

Identical chemical and physical properties of enantiomers represent a potential source for enantiomer-enantiomer interactions at both pharmacokinetic and pharmacodynamic levels. Whether by competition for plasma- or tissue-binding sites or for drug-metabolizing enzymes, enantiomers may exhibit changes in pharmacokinetics when administered as a racemate compared to individual stereoisomers. The enantiomers of disopyramide exhibit similar clearance and volumes of distribution when given separately. " However, when administered as the racemate, the 5... 

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