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Disinfectants chloroxylenol

Many derivatives of phenol are now made by a synthetic process. Homologous series of substituted derivatives have been prepared and tested for antimicrobial activity. A combination of alkyl substitution and halogenation has produced useful derivatives including clorinated phenols which are constituents of a number of proprietary disinfectants. Two ofthe most widely used derivatives are/ -chloro-m-cresol (4-chloro-3-methylphenol, chlorocresol, Fig. 10.7C) which is mostly employed as a preservative at a concentration of 0.1%, and / -chloro-m-xylenol (4-chloro-3,5-dimethylphenol, chloroxylenol. Fig. 10.7C) which is used for skin disinfection, although less than formerly. Chloroxylenol is sparingly soluble in water and must be solubihzed, for example in a suitable soap solution in conjunction with terpineol or pine oil. Its antimicrobial capacity is weak and is reduced by the presence of organic matter. [Pg.224]

Solubilization has been used for many years in the formulation of phenolic antiseptic and disinfectant solutions. In the case of Cresol and Soap Solution (Lysol) and Chloroxylenol Solution B.P., soap micelles are used to solubilize the phenolic substances. The soap (anionic surfactant) is formed by reaction of potassium hydroxide with a suitable oil such as linseed oil (in Cresol and Soap Solution) or castor oil (in Chloroxylenol Solution). The solubilizing potential of surfactant solutions for hydrophobic species has also been exploited in the design of cholelitholytic solvents for gallstone dissolution with some limited success. [Pg.3588]

Chloroxylenol is a common constituent of many proprietary disinfectants used for skin and wound disinfection see Table I. [Pg.180]

Phenolic compounds such as cresol, chloro-cresol, chloroxylenol and thymol are frequently solubilised with soap to form clear solutions which are widely used for disinfection. Solution of Chloroxylenol BP, for example, contains 5% w/v chloroxylenol with terpineol in an alcoholic soap solution. [Pg.225]

As illustrated above, various disinfectants are used for inactivation of pox viruses in laboratory, clinical and hospital facilities. However, these are generally not suitable for the home environment, posing both health and environmental hazards. Butcher and Ulaeto [15] assessed common household disinfectants on VACV and reported that a household, chloroxylenol-based disinfectant completely inactivated VACV at ambient room temperature. [Pg.140]

Ottasept . [Fttro] Chloroxylenol antimicrobial, preservative, disinfectant for industrial, chemical, arid cosmetic uses incL adhesives, shoe polishes, printing inks, cutting fluids, shampoos, medical powds., antiseptics, sanitizing soq>, cosmetics. [Pg.266]

Lysol. This is a compound of saponated cresol (mixture of 0-, m- and p-cresol) solution, usually 50% in saponified linseed oil), and was once used extensively as a disinfectant for floors and operating theaters in hospitals, p-chloro-m-cresol is the suspected allergen. It is reported to produce immediate immunological contact reactions (Sing-gih et al. 1986 Kiec-Swierczynska 1995). The patch-test concentration is 1% pet. Allergic reactions are not uncommon. Cross-reactions between p-chloro-m-cresol and p-chloro-m-xylenol (chloroxylenol) are common. [Pg.469]

Chloroxylenol (4-chloro-3,5-dimethylphenol, PCMX, parachlorometaxylenol, p-chloro-m-xyle-nol, Benzytol, Dettol, Emericide, Ottasept, CAS no. 88-04-0). This is widely used as a topical disinfectant with low irritant potential. It has been a substitute for hexachlorophene in a large number of products. It is also used as a preservative in many over-the-counter products (baby powders, shampoos, contraceptive douches, etc.) (Adams 1990). Sensitization and intoxication have been reported, but very little irritation is noticed (Myatt and Beck 1985 Ranchoff et al. 1986). The patch-test concentration is 1% pet. Irritant patch tests are common. [Pg.469]

Solutions of cresol with soap were early pharmaceutical examples of solubilized systems. Phenol itself is soluble in water to the extent of 7.7 % (w/v), but it has disadvantages the alternatives, cresol, chlorocresol, chloroxylenol, and thymol, are much less soluble in water, and their use as disinfectants has led to the need for formulation in surfactant solutions. [Pg.295]

Other Cresol-type Disinfectants and Antiseptics. Various non-irritant germicides of low toxicity, and therefore particularly suitable for disinfecting the skin and for application to wounds, contain different amounts of chloroxylenol, dichloroxylenol, benzyl cresols, o-phenylphenol, chloro-benzylphenols, special narrow-range boiling fractions of coal tar distillates, etc. They are usually dissolved in a soap, such as castor oil soap, and essential oil solution as they are only sparingly soluble in water. The various phenol coefficient tests, and particularly the Chick-Martin test, are of value in standardising such preparations, but they are of little value in determining their practical efficacy as antiseptics. For such purposes, other more specific tests are required which are beyond the scope of this book. [Pg.209]


See other pages where Disinfectants chloroxylenol is mentioned: [Pg.268]    [Pg.375]    [Pg.228]    [Pg.731]    [Pg.270]    [Pg.301]    [Pg.5099]   
See also in sourсe #XX -- [ Pg.180 ]




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