Diseases, free radicals and

McCord JM. Human disease, free radicals and the oxidant/antioxidant balance. Clin Biochem 1993 26 351-357. 

Freeman, B. A., and Crapo, J. D., 1982, Biology of disease. Free radicals and tissue injury. Lab. Invest. 47 412-426. 

Human chronic inflammatory diseases are characterized by populations of cells with altered regulation and function. A large body of evidence suggests that many of these cellular abnormalities may be linked to an increase in the production of free radicals and/or deficiencies of antioxidant defence systems. Oxygen free radicals attack cell structures, altering their function, and are cytotoxic. They have therefore been implicated in the pathogenesis of rheumatoid arthritis as well as many other human diseases (HaUiwell, 1991). 

Halliwell, B. and Gutteridge, J.M.G. (1985). Importance of free radicals and catalytic metal ions in human disease. Mol. Aspects Med. 8, 89-193. 

Harris, M.L., Schiller, H.J., Reilly, P.M., Donowitz, M., Grisham, M.B. and Bulkley, G.B. (1992). Free radicals and other reactive oxygen metabolites in inflammatory bowel disease cause, consequence or epiphenomenon Pharmac. Ther. 53, 375-408. 

Sanfey, H. (1991). Free radicals and antioxidants in pancreatic inflammation. In Pancreatic Disease (eds. C.D. Johnson and C.W. Imrie) pp. 241-250. Springer-Verlag, London. 

Free Radicals and Muscle Fatigue 176 6. Muscle Diseases 180... 

Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M and Telser J. 2007. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39 44-84. 

Free Radicals and Oxidative Stress in Pathophysiological Processes 31.1 Cardiovascular Diseases... 

B. Bagchi, M. Bagchi, S.J. Stohs, D.K. Das, S.D. Ray, C.A. Kuszynski, S.S. Joshi and H.G. Pruess, Free radicals and grape seed proanthocyanidin extract importance in human health and disease prevention. Toxicology 148 (2000) 187-197. 

Levine, R. L. (2002). Carbonyl modified proteins in cellular regulation, aging and disease. Free Radic. Biol. Med. 32, 790-796. 

Androgen deprivation therapy (ADT) is being used increasingly as neo-adjuvant and adjuvant therapy. Neo-adjuvant ADT for 4-6 months before external beam radiation can enhance survival and reduce the prostate volume to be irradiated. Similar benefits have not been seen prior to radical prostatectomy. The benefits of neo-adjuvant therapy are most evident for high risk localized prostate cancer. Adjuvant ADT for up to 2 years following external beam radiation increases disease-free survival and overall survival for locally advanced (T3) tumors. 

Widlansky, M.E., Duffy, S.J., Hamburg, N.M., Gokce, N., Warden, B.A., Wiseman, S., Keaney, J.F., Jr., Frei, B., and Vita, J.A., Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radical Biol Med, 38, 499, 2005. 

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