Free Radicals in Gastrointestinal and Hepatic Disease

The purpose of this chapter is to examine, in some detail, the evidence that abnormal metabolism of free radicals is of pathogenic importance in a number of diseases. In order to do this, the contribution of free radicals to the inflammatory or pathological process will be 

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1 Free radicals should be present in increased quantities at the site of injury. 

2 Exogenous application of free radicals should reproduce or enhance the changes observed. 

3 Agents that prevent the formation or release, or that block the effects of free radicals should prevent or ameliorate the changes observed. 

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