Disease identification

Goedert, M. et al. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease Identification as the microtubule-associated protein tau. Proc. Natl. Acad. Sci. USA 85 4051-4055, 1988. 

Gaylord BS, Massie MR, Feinstein SC, Bazan GC (2005) SNP detection using peptide nucleic acid probes and conjugated polymers applications in neurodegenerative disease identification. Proc Natl Acad Sci USA 102 34—39... 

Lue LF, Walker DG, Brachova L, Beach TG, Rogers J, Schmidt AM, Stem DM, Yan SD. 2001. Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer s disease identification of a cellular activation mechanism. Exp Neurol 171(1) 29 15. 

Van Broeckhoven CL. 1995. Molecular genetics of Alzheimer s disease identification of genes and gene mutations. Eur Neurol 35 8-19. 

Improvements in medication by use of acetyl cholinesterase inhibitors and general therapy significantly reduce symptoms at the onset of the disease [3, 4] but do not address the severe mortality in the final stages. A causal therapy is, therefore, still very much in demand, because no existing therapy effectively stops or even cures the disease. Identification of gene mutations linked to Alzheimer s disease-afflicted families in London and Sweden and additional polymorphisms that either cause or promote Alzheimer s disease have provided some insight into the biological pathways and the involvement of the amyloid precursor protein (APP) [5-8],... 

Molecular analysis of the presenilin 1 (S182) gene in sporadic cases of Alzheimer s disease identification and characterisation of unusual splice variants. J Neurochem 66 1774-1777... 

The nature of a particular disease can help you predict whether control is necessary hence the importance of disease identification. Noninfectious diseases do not spread from one plant to the next. For instance, leaf yellowing due to iron deficiency on an azalea planted in alkaline soil will not spread to nearby healthy azaleas planted in acidic soil. While you should take steps to revitalize the affected plants, you won t have to do anything to protect the healthy plants. 

Belair J, Glass L, An Der Heiden U, Milton J (1995) Dynamical disease identification, temporal aspects and treatment strategies of human illness. Chaos 5 1-7... 

Alternate Names other names, which differ among geographical areas sometimes confusing disease identification and reporting. 

SRM which include CNS tissue are tissues from animals that are known to carry, transfer, or perpetuate infectivity of the BSE causative agent, prions. Because BSE is an adult-onset disease, identification of tissues as SRM is dependent on the age of the animal at slaughter, and definitions of SRM vary by country, based on differences in interpretation of scientific evidence and the amount of risk allowed (Table 1). Care must be taken when removing SRM (including CNS tissue) to prevent contamination of products due to improper or incomplete removal of SRM and to prevent cross-contamination of SRM to meat products via personnel or equipment. 

Mohler ER, 3rd. Peripheral arterial disease. Identification and implications. Arch IntMed 2003 163(2306-2314). 

Knowledge of cellular signaling pathways and knowledge of the human genetics of a specific disease provide powerful validation and rational targets for disease identification and development of drags and therapies. 

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