Discovery and Structure

In the early 1960s ergot alkaloids were also discovered in higher plants when Albert Hofmann was able to elucidate the hallucinogenic principle of the two 

Ergot alkaloids are usually divided into three main structural types two of which include a lysergic acid amide moiety (Fig. 4.2)  

The names of those alkaloids which belong to these two types generally begin 

Clavines are minor alkaloids of the mature sclerotium of Claviceps purpurea. However, agroclavine is the major alkaloid of a certain earlier developmental stage of this fungus together with other clavines it is a biogenetic precursor of the 

Surprisingly, members of all three structural types, i.e., ergopeptines, simple lysergic acid amides, and clavines turned out to be constituents of certain convolvulaceous species. Furthermore, this is also true for aU four groups of clavines. 

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With the discovery and structure elucidation of bonellin (1) and factor I (2), both naturally occurring chlorins. the systematic investigation of total synthetic approaches leading to these natural products and other chlorins was induced.4... 

Astles PC, Brown TJ, Handscombe CM, Harper MF, Harris NV, Lewis RA, Lockey PM, McCarthy C, McLay IM, Porter B, Roach AG, Smith C, Walsh RJA. Selective endothelin A receptor antagonists. 1. Discovery and structure-activity of 2,4-disubstituted benzoic acid derivatives. Eur J Med Ghent 1997 32 409-23. 

Wacker DA, Santella JB 3rd, Gardner DS, et al. CCR3 antagonists a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships. Bioorg Med Chem Lett 2002 12(13) 1785-1789. 

Barker, J. J. (2006). Antibacterial drug discovery and structure-based design. Drug Discov. Today 11, 391 104. 

Lee DL, PrisbyUaMP, CromartieTH, Dagarin DP, Howard SW, Provan WM, EUis MK, Fraser T, Mutter LC, The discovery and structural requirements of inhibitors of hydroxyphenylpyruvate dioxygenase. Weed Sci 45 601—609,... 

Because of these collection rates, high-throughput synchrotron operations are as much an issue of sample and data management as of data collection. For this reason, SGX-CAT operations were included in the information management systems for the structural biology platform at SGX at the time of beamline commissioning. These data systems directly link beamline operations to SGX efforts in drug discovery and structural proteomics. 

The discovery and structural elucidation of ferrocene in 1951 and the subsequent development of metal-cyclopentadienyl chemistry started a new era in organometallic chemistry . 

II. Peptide Ligand Lead Discovery and Structure-Based Drug Design... 

Alexander Fleming, Ernst B. Chain, and Howard W. Florey Physiology/Medicine Discovery and structure of penicillin... 

Wendt, M. D Shen, W Kunzer, A., McClellan, W. J., Bruncko, M., Oost, T. K., et al. Discovery and Structure-Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity In Vitro and In Vivo. J. Med. Chem. 2006, 49, 1165-1181. 

H. Ottinger, T. Soldo, and T. Hofmann, Discovery and structure determination of a novel Maillard-derived sweetness enhancer by application of the comparative taste dilution analysis (cTDA), J. Agric. Food Chem., 2003, 51, 1035-1041. 

Watson, James D. The Double Helix A Personal Account of the Discovery and Structure of DNA. New York Atheneum, 1968. 

Me Alpine JB, et al. Microbial genomics as a guide to drug discovery and structural elucidation ECO-02301, a novel antifungal agent, as an example. J. Nat. Prod. 2005 68 493 96. 

De Lucca GV, Kim UT, Johnson C, Vargo BJ, Welch PK, Covington M, Davies P, Solomon KA, Newton RC, Trainor GL, Decicco CP, Ko SS. Discovery and structure-activity relationship of N-(ureidoaIkyl)-benzyl-piperidines as potent small molecule... 

Discovery and Structure of Solid Inorganic Ion Exchange Materials... 

When the previous chapter (i) on the quinoline alkaloids was completed in 1957, the chemistry of the dictamnine group of alkoxyfuro-quinolines was already well established. The present account records the isolation of already known alkaloids of this group from a much larger number of plant sources and the discovery and structural elucidation of... 

The variety of MS-based approaches [see Fig. (1) and Fig. (2) for a general view of the strategies] that have been used to discover, identify and elucidate effectors of the Drosophila immune defense reactions is presently reviewed.Regardless of the approach, MS allowed the discovery and structural characterization of an unprecedented number of systemic immune effectors, as well as the detection of such effectors within tissues expressing a local immune response. 

Anraky, Y., R. Mizutani, and Y. Satow. 2008. Protein splicing Its discovery and structural insight into novel chemical mechanisms. IUMBMB 57, 563-574. 

Wendt MD, Shen W, Kunzer A et al (2006) Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo. J Med Chem 49 1165-1181... 

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