Discovery and Structure Elucidation

Nicotine is also accumulated in considerable proportions in other Nicotiana species and in a few species of some other solanaceous genera, e.g., Duboisia (for details see below). Moreover, it was detected in extremely small amounts in species of several other genera of this family. Furthermore, it is also a common minor component in the Convolvulaceae beside pyrrolidine and tropane alkaloids (for details see below). 

Occurrence in Non-solanaceous/Non-convolvulaceous Taxa. Like the Solanales the unrelated genus Erythroxylum P. Browne (Erythroxylaceae) also shows cooccurrence of nicotine (low concentrations) and pyrrolidines and tropanes (Steinegger 1972). Furthermore, due to its relatively simple biosynthesis close to the priinary metabolism (Sect. 3.3.4), the sporadic occurrence of nicotine in several unrelated famihes found throughout the plant kingdom is not very surprising. Thus, nicotine 

SvBGENVS (according to Goodspeed 1954, not mono-phyletic, see text) 

cutleri D Arcy (no data) Thyrsiflorae GooDSP. (former monotypic section, omitted by Knapp et al. 2004) Rusticae G.Don N. rustica L. ++ + ++ + + 

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With the discovery and structure elucidation of bonellin (1) and factor I (2), both naturally occurring chlorins. the systematic investigation of total synthetic approaches leading to these natural products and other chlorins was induced.4... 

The discovery and structural elucidation of ferrocene in 1951 and the subsequent development of metal-cyclopentadienyl chemistry started a new era in organometallic chemistry . 

Me Alpine JB, et al. Microbial genomics as a guide to drug discovery and structural elucidation ECO-02301, a novel antifungal agent, as an example. J. Nat. Prod. 2005 68 493 96. 

When the previous chapter (i) on the quinoline alkaloids was completed in 1957, the chemistry of the dictamnine group of alkoxyfuro-quinolines was already well established. The present account records the isolation of already known alkaloids of this group from a much larger number of plant sources and the discovery and structural elucidation of... 

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