Microbial genomes

Science (microbial community genomics microbial in situ bioremediation proteomics and metabolomics PCR and revolutions in microbiology (6) engineering (bioprocessing, biotechnology, combining unit operations) (2)... 

Price ND, Papin JA, Schilling CH, Palsson BO. Genome-scale microbial in silico models the constraints-based approach. Trends Biotechnol 2003 21 162-9. 

Genomic and molecular tools have made great impacts on plant biotechnology and offer potential for manipulation of carotenoids as natural colorants and also for applications in human and animal health. While microbial and other non-plant systems have been successfully used, plant modification eliminates need for expensive bioreactors and offers economically feasible opportunities for less developed nations for production of nutraceuticals and other chemical products. 

These studies have revealed a number of cardinal aspects of microbial ecology (a) the complexity of bacterial ecosystems, (b) the number of organisms of hitherto undetermined taxonomy, (c) the existence of organisms that have not been cultivated, and (d) the difficulty of assigning metabolic roles to many of the genomic sequences that have been revealed. Some examples are given to... 

Telang AJ, S Ebert, LM Focht, DW Westlake, GE Jenneman, D Gevertz, G Voordouw (1997) Effect of nitrate injection on the microbial community in an oil field monitored by reverse sample genome probing. Appl Environ Microbiol 63 1785-1793. 

Genome-Based Approaches to Investigate Microbial Metal Resistance Mechanisms... 

Greene, E. A. Voordouw, G. Analysis of environmental microbial communities by reverse sample genome probing. J. Microbiol. Meth. 2003,53,211-219. 

Wellington, E. M. H. Berry, A. Krsek, M. Resolving functional diversity in relation to microbial community structure in soil Exploiting genomics and stable isotope probing. Curr. Opin. Microbiol. 2003, 6,295-301. 

HIGH-THROUGHPUT MICROBIAL CHARACTERIZATIONS USING ELECTROSPRAY IONIZATION MASS SPECTROMETRY AND ITS ROLE IN FUNCTIONAL GENOMICS... 

Van Lanen, S.G. and Shen, B. (2006) Microbial genomics for the improvement of natural product discovery. Current Opinion in Microbiology, 9, 252. 

The possibility of customization is the principal scientific advantage of the system. The microarray design, layout, and format are specific for each scientist s needs and objectives. The Design-on-Demand service offer by CombiMatrix try to cover this versatility. The researcher, though would define his experimental strategy with CombiMatrix support. Available libraries include eukaryotic, microbial, and viral genomes. Direct customer services are also offered. 

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