Directed metalation, pharmaceutical industry

In a catalytic asymmetric reaction, a small amount of an enantio-merically pure catalyst, either an enzyme or a synthetic, soluble transition metal complex, is used to produce large quantities of an optically active compound from a precursor that may be chiral or achiral. In recent years, synthetic chemists have developed numerous catalytic asymmetric reaction processes that transform prochiral substrates into chiral products with impressive margins of enantio-selectivity, feats that were once the exclusive domain of enzymes.56 These developments have had an enormous impact on academic and industrial organic synthesis. In the pharmaceutical industry, where there is a great emphasis on the production of enantiomeri-cally pure compounds, effective catalytic asymmetric reactions are particularly valuable because one molecule of an enantiomerically pure catalyst can, in principle, direct the stereoselective formation of millions of chiral product molecules. Such reactions are thus highly productive and economical, and, when applicable, they make the wasteful practice of racemate resolution obsolete. 

It is common practice in pharmaceutical industry to generate salt forms of a drug substance to improve solid-state properties and solubility. CE has proven its ability to analyze reliably organic acids (direct, indirect detection) and alkaline/earth alkaline metals and basic amino acids. For basic drugs, a non-toxic organic acid or inorganic acid is chosen as counterion. Acidic drug substances will usually be deprotonated by alkaline and earth alkaline... 

The third difference is that the products commercialized by the two sets of industries were dramatically different and directed toward different markets. Consumer electronics and computers transformed the ways of communication through sound (audio), sight (video), and manipulation of information (computers). Their products required two sets of hardware devices, one for transmission and the other for reception, with software to process the information within both and that flowing between them. The mature chemical and pharmaceutical industries, on the other hand, utilized the new scientific knowledge to create a vast array of new materials and medicines that replaced natural ones—metal, wood, and other organic products—that... 

Indirectly fired furnaces find applications in metallurgy, paint enameling, the pharmaceutical industry, and other situations where it is necessary to control the chemistry of the furnace atmosphere [186]. An important aspect of the heat treatment of metals, for example, is the effect of the furnace atmosphere on the stock being heated. In most cases, the need is to minimize or eliminate completely the undesirable effects of furnace gases, such as oxidation or decarbonization. Both directly [187,188] and indirectly [189,190], natural-gas-fired furnaces have been analyzed, but the details cannot be included here. 

Offers direct access to virtually all of the world s scientific and data bases for toxicology and related information. Covers chemicals, pesticides, food additives, industrial chemicals, heavy metals, environmental pollutants, and pharmaceuticals. The Center is online to more than 400 computerized databases, including DIALOG, MEDLARS, STN International, ITIS, and DROLS. It performs searches for outside users for a fee. 

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