Diphosphopyridine nucleotide, reduced

Diphosphopyridine nucleotide, reduced form Adenine-D-ribose-phosphate-phosphate D-ribose-nicotinamide, reduced form Cozymase, reduced form... 

DPN, DPNH diphosphopyridine nucleotide, reduced diphosphopyri-dine nucleotide... 

Deoxycorticosterone Deoxycorticosterone acetate Diphosphopyridine nucleotide Reduced diphosphopyridine nucleotide Electron... 

P-Nicotinamide adenine dinucleotide reduced di-Na salt trihydrate (reduced diphosphopyridine nucleotide sodium salt, NADH) [606-68-8] M 763.5, pK as for NAD. 

Nicotinamide adenine dinucleotide phosphate reduced tetrasodium salt (reduced diphosphopyridine nucleotide phosphate sodium salt, NADPH) [2646-71-1] M 833.4, pK as for NADP. Mostly similar to NADH above. 

The reduced form of diphosphopyridine nucleotide (DPNH), which is used in the reduction of di-O-phosphoglyceronic acid to O-phosphoglycerose, could be regenerated with high efficiency from the oxidized form (DPN ) by the reduced form of 6-thioctic acid, thus supplying the necessary re-... 

The reduction of aromatic nitro compQunds (see p. 98) is also due to the action of an enzyme system in which a dehydrogenase transfers hydrogen to a diphosphopyridine nucleotide-flavoprotein, which in turn reduces the nitro group (Westfall, as well as Bueding and Jolliffe ). 

Nicotinamide adenine dinucleotide reduced disodium salt trihydrate (reduced diphosphopyridine nucleotide sodium salt, NADH) [606-68-8/ M 763.5. This coenzyme is available in high purity and it is advised to buy a fresh preparation rather than to purify an old sample as purification will invariably lead to a more impure sample contaminated with the oxidised form (NAD). It has... 

The reduced form of the respiratory coenzyme diphosphopyridine nucleotide (DPNH), which is vitally important for all cellular metabolism, is changed by dilute acid to a substance that, in the light of the following model experiments, may be a covalent hydrate. The 1,4-and 1,6-dihydro derivatives of l-benzylpyridine-3-carboxamide furnish a single substance when dissolved in dilute acid at 20° and the solution is basified. The stable yellow product, which has a prominent peak at 292 nm, was assigned the constitution 1-benzyl-6-hydroxy-1,4,5,6-tetra-hydropyridine-3-carboxamide61 (see Scheme 2). 3-Acetyl-1 -benzyl- 1,4-... 

Boyer, P.D. and Theorell, H. The change in reduced diphosphopyridine nucleotide (DPNH) fluorescence upon combination with liver alcohol dehydrogenase (ADH). Acta Chem. Scand., 10 447-450, 1956. 

Winer, A.D., Schwert, G.W. and Millar, D.B.S. Lactic dehydrogenase. VI. Fluorometric measurements of the complex of enzyme and reduced diphosphopyridine nucleotide. 

Fio. 7.—Tentative Mechanism for the Enzymic Conversion of 3-Deoxy-n-aro5mo-heptulosonic Acid 7-Phoaphate to 6-Dehydroquinic Acid. (DPN denotes diphosphopyridine nucleotide and DPNH is reduced diphosphopyridine nucleotide.)... 

Nicotine adenine dinucleotide ( diphosphopyridine nucleotide ) appears to be necessary in this transformation, although none of the reduced form accumulates E. S. Maxwell, J. Am. Chem. Soc., 78, 1074 (1056) see also. Ref. 125. 

The following abbreviations will be used ADH—alcohol dehydrogenase DPN — diphosphopyridine nucleotide DPNH—reduced diphosphopyridine nucleotide OP—1,10-phenanthroline 8-OHQ—8-hydroxyquinoline a,a -D—a,a -dipyridyl 8-OHQ5SA—8-hydroxyquinoline-5-sulfonie acid TU—thiourea EDTA—ethylene-diamine tetraacetic acid zincon —2-carboxy-2 -hydroxy-5-sulformazylbenzene diamox — sodium 2 - acetylamino -1,3,4- thiodiazole - 5 - sulf onamide NaDDC — so -dium-diethyldithiocarbamate CGP—carbobenzoxyglycyl-L-phenylalanine. 

Correia, M.A. and G.J. Mannering (1973). Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of... 

Frenkel, R. 1968. Control of reduced diphosphopyridine nucleotide oscillations in beef heart extracts. I. Effect of modifiers of phosphofructokinase activity. Arch. Biochem. Biophys. 125 151-6. 

Among the spectra of coenzymes given by Rosenkrantz were glutathione (reduced and oxidized), diphosphopyridine nucleotide (DPN or NAD ) and its reduced form (Na salt), triphosphopyridine nucleotide and its reduced form (Na salt), flavin mononucleotide, flavin adenine dinucleotide, oxidized cytochrome c (containing some of the reduced form), and thiamine pyrophosphate. 

As indicated in Fig. 1, the initial step in the pathway outlined by Langdon (19,57) was believed to be the condensation of two acetyl CoA units to yield acetoacetyl CoA. Reduction of acetoacetyl CoA then followed, and in this mammalian liver system reduced diphosphopyridine nucleotide w as the hydrogen donor for this reaction. The resulting a-hydroxy-acyl-CoA com-... 

It would be well to point out a few examples which illustrate the overlap of asymmetric reduction studies and molecular biochemistry. Diphosphopyridine nucleotide (DPN) and triphospho-pyridine nucleotide (TPN) are important coenzymes in biochemical oxidation reduction reactions. Certain enzymes function as catalysts for the reversible transfer of hydrogen between these nucleotides and a substrate for which the enzyme is specific. For example, DPN and the enzyme, alcohol dehydrogenase (ADH), form a redox system with ethanol. Using deuterium labeled reducing agent and substrate, Westheimer, Vennesland,... 

---