3.3- dimethoxy-l-propenyl

B. (l-Azido-3,3-dimethoxy-l-propenyl)benzene. In a 2-1., one-necked, round-bottomed flask equipped with a magnetic stirrer and powder funnel are placed 156 g. (0.45 mole) of the iodoazide from Part A and 1500 ml. of anhydrous ether. The solution is stirred and cooled in an ice-salt bath (— 5° to 0°), and 62 g. (0.55 mole) of potassium <-butoxide (Note 6) is added. The powder funnel is then replaced by a calcium chloride drying tube and the mixture is stirred for 4 5 hours at 0°. At the end of this time 350 ml. of water is added while the mixture is still cold. The ethereal layer is then separated and washed with three 350-ml. portions of water and dried over magnesium sulfate. The solvent is removed with a rotary evaporator without heating, leaving 67-75 g. (68-76%) of (l-azido-3,3-dimethoxy-l-propenyl)-benzene as a dark oily liquid (Note 7). This material can be used without further purification for Part C (Note 8). 

Arylphosphonic acid derivatives, 58, 137 Arylphosphonic dichlorides, 58, 136 Aryltetrachlorophosphoranes, 58, 137 L-Asparagine, carbobenzoxy-, 56, 89 L-Asparagine, NJ-(tnfluoroacetyl)- 56, 125 L ASPARAGINYL-L-LEUCINE, CARBOBENZOXY-,METHYL ESTER, 56, 88 Z-Asp Gly-OEt, 56, 93 (l-Azido-3,3-dimethoxy-l-propenyl)ben-zene, 57, 84... 

Dimethoxy-5,5 -di-2-propenyl[l,r-biphenyl -2,2 -diol, 9Cl. 5,5 -Diallyl-2,2 -dihydroxy-3,3 -dimethoxybiphenyl. 6 -4,4 -Dihydroxy-5,5 -dimethoxy-3,3 -neolignan. 

CN (3p,16p,17a,18P,20a)-ll,17-dimethoxy-18-[[l-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]oxy]yohimban-16-carboxylic acid methyl ester... 

The allylic amination with benzylamine or related amines such as (3,4-dimethoxy-phenyl)methylamine catalyzed by palladium coordinated with the dihydroxylated ferrocenylphosphine 8b takes place with high enantioselectivity (Scheme 2-30) [27]. Thus, reaction of l,3-diphenyl-2-propenyl ethyl carbonate 41 with benzylamine gives a quantitative yield of allylic amination product 42 with > 97% ee. High enantioselectivity is also obtained in the allylic amination of 2-propenyl esters 43 substituted... 

Dimethoxy-4-hydroxycinnamaldehyde Phenol, 2,6-dimethoxy Eugenol 2-Methoxy-6-methylphenol Vanillin Phenol, 2-methoxy-4-(l-propenyl) S additional peaks 3, S-Dimethoxy-4-hydroxycinnamaldehyde... 

Phenylpropanoid-type compounds have been isolated as the algal inhibitory constituents from the aquatic plant Acorus gramineus [92] using a filter paper-dish bioassay. It was noted that 1,2-dimethoxy-4-(E-3 -methyloxiranyl) benzene (10), l,2,4-trimethoxy-5-(Z-l -propenyl)benzene (11), l,2,4-trimethoxy-5-(E-3 methyloxiranyl)benzene (12), the three most abundant phenylpropanes isolated, were either inhibitory or not in each of the cyanobacterial strains tested which included Anabaena flos-aquae, Nostoc commune, and Synechococcus leopoliensis. 

Hydroxy-3,4-dimethoxy-5-(2-propenyl)phenyl]ethanone, 946 1 -[2-Hydroxy-4,6-dimethoxy-3-(2-propenyl)phenyl]ethanone, 946 1 -[3-Hydroxy-4,6-dimethoxy-2-(2-propenyl)phenyl]ethanone, 946 1 -[2-Hydroxy-4-[(tetrahydro-2//-pyran-2-yl)oxy]phenyl]ethanone, 946 1 -[2-Hydroxy-6-[(tetrahydro-2//-pyran-2-yl)oxy]phenyl]ethanone, 947 1 -[2,3,4-Trihydroxy-5-(3-methyl-2-butenyl)phenyl]ethanone, 947 1 -[2,3,4-Trihydroxy-6-(3-methyl-2-butenyl)phenyl]ethanone, 947 l-[2,4,6-Trihydroxy-3-(3-methyl-2-butenyl)phenyl]ethanone, 947... 

Two approaches for the synthesis of allyl(alkyl)- and allyl(aryl)tin halides are thermolysis of halo(alkyl)tin ethers derived from tertiary homoallylic alcohols, and transmetalation of other allylstannanes. For example, dibutyl(-2-propenyl)tin chloride has been prepared by healing dibutyl(di-2-propenyl)stannane with dibutyltin dichloride42, and by thermolysis of mixtures of 2,3-dimethyl-5-hexen-3-ol or 2-methyl-4-penten-2-ol and tetrabutyl-l,3-dichlorodistannox-ane39. Alternatively dibutyltin dichloride and (dibutyl)(dimethoxy)tin were mixed to provide (dibutyl)(methoxy)tin chloride which was heated with 2,2,3-trimethyl-5-hexen-3-ol40. 

When isomerization of the double bond of the intermediate cyclopropene into the exo methylene position is energetically unfavored, double elimination followed by double addition of base can occur. Thus, reaction of (cu/tra i )-l,l-dichloro-2-methyl-3-vinylcyclopropane (9) with potassium terf-butoxide plus methoxide in dimethyl sulfoxide gave a mixture of cis- and trans-, -dimethoxy-2-methyl-3-vinylcyclopropane (10). Both double bonds formed via elimination appear to be conjugated with the vinyl group and do not migrate to the exo position. The similar reaction of l,l-dichloro-2-[( )-propenyl]cyclopropane (11) gave a small amount of 1-/ert-butoxy-2-(prop-2-enylidene)cyclopropane (13) in addition to products of double addition. Without added methoxide, 13 was the only product isolated. ... 

IMDA reaction of l,2,3,4-tetrahydro-6,7-dimethoxy-2-(l-oxo-2,4-pentadienyl)-l-(2-propenyl)isoquinoline, formed by reaction of tributyl(2-propenyl)tin with 3.4-dihydro-6,7-dimethoxyisoquinoline activated with ( )-2,4-pentadienoyl chloride, gave a ca. 20 1 mixture of cycloadducts41. 

Obtained at -78° in THF using lithium diisopropyl-amide (LDA), either by reaction between methyl 2-hydroxy-4,6-dimethoxy-3-(2-propenyl)-benzoate and (R)-(-i-)-methyl p-tolyl sulfoxide in the presence of l,3-dimethyl-3,4,5,6-tetrahydro-2[lW]-pyrimidinone (DMPU) (this method yields only a trace of the desired compound), or by reaction between 2-hydroxy-4,6-dimethoxy-3-(2-propenyl)benzaldehyde and (R)-(-b)-methyl p-tolyl sulfoxide via the subsequent oxidation % r.t. by MnO of the intermediate l-[2-hydroxy-4,6-dimethoxy-3-(2-propenyl)phenyl]-2-(4-methylsulfmyl)ethanol (57%) [5602]. 

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