Dimercaptopropane

Acetone, (reduction with) ascorbic acid, citrate, CE, CN , 2,3-dimercaptopropan-I-oI, EDTA, formate, E, 8CN , 80 , tartrate, thiosemicarbazide, thiourea, triethanolamine CE, EDTA, F , 8CN , tartrate, thiourea, triethanolamine Citrate, CN , 8CN , tartrate, thiourea Citrate, EDTA, F , oxalate, tartrate, tiron... 

The reaction proceeds easily (0°C, 30 min) after mixing of the reagents. Under analogous conditions, from 1,3-dimercaptopropane 2-dialkylamino-4-methyl-8//-6,7-dihydro-1,5-dithiocins (106) were obtained in yields of 67 and52% (88ZOR88). 

Hg Acetone, (reduction with) ascorbic acid, citrate, Cl-, CN-, 2,3-dimercaptopropan-l-ol, EDTA,... 

Dargan PI et al Case report Severe mercuric sulphate poisoning treated with 2,3-dimercaptopropane-l-sulphonate and haemodiafiltration. Crit Care 2003 7 Rl. 

Abbreviations DHG = Ar,Ar-di(2-hydroxyethyl)glycine NTA = nitrilotriacetic acid EDTA = ethylenediaminetetraacetic acid tiron = pyrocatechol-3,5-disulfonic acid BAL = 2,3-dimercaptopropanol unithiol = sodium 2,3-dimercaptopropane sulfonate tren — triaminatriethylamine penten = tetrakis(aminoethyl)ethylenediamine bipy = 2,2 -bipyridyl phen = 1,10-phenanthroline. 

BAL is lipid soluble and it has the ability to remove metal deposits not available to attack by other chelators. More effective and less toxic compounds have since become available these include vicinal dithiols, other dithiols, aminocarboxylic acids, cysteine derivatives, and others. Unithiol (sodium 2,3-dimercaptopropane-l-sulfonate DMPS) forms very stable, water soluble complexes with Hg2+, Pb2+, Cd2+, Zn2+, Bi3+, As3+, Sb2+ and Ni2+. The complexes are nearly all less toxic than... 

Antidotal effects of 2,3-dimercaptopropane-l-sulfonic (DMPS) and meso-2,3-dimercaptosuccinic (DMSA) acids on the toxicity of dibutyltin dichloride in rats were... 

Trivalent arsenic forms strong bonds with sulfur, and thiols are therefore used for derivatizing both lewisite and CVAA, forming the same derivative (19). Lewisite reacts with mono and dithiols the reaction with dithiols occurring rapidly at ambient temperature. In a competitive environment, lewisite reacts almost exclusively with dithiols rather than monothiols (35). Three dithiols, 1,2-ethanedithiol, 1,3-propanedithiol and 2,3-dimercaptopropan-l-ol (British Anti-Lewisite, BAL) have been used for biomedical sample analysis of CVAA to form cyclic derivatives (14a, b) and (15). Unlike derivatiza-tion of TDG, CVAA can be derivatized direcdy in an aqueous solution. 2,3-Dimercaptotoluene, which has been used extensively for environmental analysis (19), does not appear to have been used. 

Aposhian, H.V., Bmce, D.C., Alter, W., Dart, R.C., Hurlbut, K.M., Aposhian, M.M. (1992). Urinary mercury after administration of 2,3-dimercaptopropane-l-sulfonic acid correlation with dental amalgam score. EASES J. 6 2472-6. 

Hauser, W., Weger, N. (1989). Treatment of arsenic poisoning in mice with sodium dimercaptopropane 1-sulfonate. nProc. Int. Cong. Pharmacol., Paris (abst.). 

Pant, S.C., Vijayaraghavan, R., Kannan, G.M., Ganesan, K. (2000). Sulfur mustard induced oxidative stress and its prevention by sodium 2,3-dimercaptopropane sulfonic acid (DMPS) in mice. Biomed. Environ. Sci. 13 225-32. 

SYNS BRITISH ANTILEWISITE DICAPTOL DIMERCAPROL PROPANOL DIMERCAPTOL 2,3-DIMERCAPTOL-l-PROPANOL DIMERCAPTOPRO-PANOL 2,3-DIMERCAPTOPROPANOL 2,3-DIMERCAPTOPROPAN-l-OL DITHIOGLYCEROL 1,2-DITHIOGLYCEROL 2,3-DITHIOPROPANOL SULFACTIN USAF ME-1... 

DIMERCAPTOPROPAN-l-OL see BAD750 DIMERCUROUS METHANE ARSONATE see DNWOOO DIMER CYKI,OPENTADIENU (CZECH) see DGWOOO... 

Dimercaptopropane sulfonate (2,3-dimercapto-l-propane-sulfonate) is a water-soluble and possibly less toxic derivative of dimercaprol, used in poisoning with arsenic, bismuth, mercury, and other heavy metals. 

Dimercaptopropane sulfonate is the treatment of choice for acute arsenic poisoning and has been used safely in high doses (15.25 g in 12 days, first intravenously and later orally) in a 21-year-old man who swallowed about 1000 mg or more of arsenic trioxide (1). There were no adverse effects. A modest transient increase in serum transaminases was thought to have been due to the arsenic. 

In a UK study, single oral doses of dimercaptopropane sulfonic acid or succimer in different combinations with or without acetylcysteine and potassium citrate were given to 191 patients considered to have mercury toxicity from amalgam dental fillings (2). After a single dose, about 5% of patients complained of mild gastrointestinal discomfort, fatigue, mental fuzziness, headache, and diuresis. These usually cleared within 6 hours of the dose and were considered to be due to heavy metal mobilization. There were no cases of hypersensitivity. 

Reported adverse effects of dimercaptopropane sulfonate include nausea, vertigo, headache, weakness, pruritus, and allergic reactions, such as rashes (3-6). Nausea can occur after both oral and intravenous administration. 

Dargan PI, Giles LJ, Wallace Cl, et al. Case report severe mercuric sulphate poisoning treated with 2, 3-dimercaptopropane-1-sulphonate and haemodiafiltration. Cr/f Care. 2003 7 R1-6. 

Garza-Ocanas L,Torres-Alanis O, Pineyro-Lopez A. Urinary mercury in twelve cases of cutaneous mercurous chloride (calomel) exposure effect of sodium 2, 3-dimercaptopropane-l-sulfonate (DMPS) therapy. J Toxicol Clin Toxicol 1997 35(6) 653-5. 

CHF congestive heart failure DMPS dimercaptopropane 1 sulphonate... 

---