Aminocarboxylic acid

Supplement 1942 195-449 Hydroxy-amines Aminoethyl alcohol, 274. Carbonyl-amines Aminoacetaldehyde, 307. Aminoacetone, 314. Hydroxy-carbonyl amines Glucosamine, 328. Aminocarboxylic acids Glycine, 333. Hydroxylamines, 534. Hydrazines, 546. Azo Compounds. 562. Oryano-metallic Compounds, 580. 

The utility of complexation titrations improved following the introduction by Schwarzenbach, in 1945, of aminocarboxylic acids as multidentate ligands capable of forming stable 1 1 complexes with metal ions. The most widely used of these new ligands was ethylenediaminetetraacetic acid, EDTA, which forms strong 1 1 complexes with many metal ions. The first use of EDTA as a titrant occurred in... 

Recently, a novel process for the preparation of chromia promoted skeletal copper catalysts was reported by Ma and Wainwright (8), in which Al was selectively leached from CuA12 alloy particles using 6.1 M NaOH solutions containing different concentrations of sodium chromate. The catalysts had very high surface areas and were very stable in highly concentrated NaOH solutions at temperatures up to 400 K (8, 9). They thus have potential for use in the liquid phase dehydrogenation of aminoalcohols to aminocarboxylic acid salts. 

In today s discussion of the origin of life, the RNA World (Chapter 6) is seen as much more important, and is much better publicized, than the protein world . However, nucleic acids and proteins are of equal importance for the vital metabolic functions in today s life forms. Peptides and proteins are constructed from the same building blocks (monomers), the aminocarboxylic acids (generally known simply as amino acids). The way in which the monomers are linked, the peptide bond, is the same in peptides and proteins. While peptides consist of only a few amino acids (or to be more exact, amino acid residues), proteins can contain many hundreds. The term protein (after the Greek proteuein, to be the first) was coined by Berzelius in 1838. 

After hydrolysis of the nitrile to the aminocarboxylic acid, the authors obtained the dipeptide diglycine (Gly-Gly) and the tripeptide Gly-Gly-Gly. 

Chart 6. Aminocarboxylic acids used as ligands on bismuth. 

Table 5.11 Some additional aminocarboxylic acid ligands... 

In the aminosulphonic acids the electrochemical character of both substituents is appreciably weakened, as it is in aminocarboxylic acids... 

The beneficial effect of surfactants on enantioselective hydrogenations in water was exploited in the synthesis of a-aminophosphinic and a-aminophosphonic acids. These compounds are stmctural analogues of a-aminocarboxylic acids and their peptides find use as herbicides, bactericides and antibiotics [150,151]. With [Rh(BPPM)(COD)]Bp4 and similar catalysts fast ractions and e.e.-s up to 98% could be obtained in water in the presence of SDS (Scheme 3.12). 

Scheme 61. Preparation of racemic (208) and enantiomerically pure (207, 213) spiropentane aminocarboxylic acids from the Michael adducts 102 of (4J ,5S)-4,5-diphenyloxazolidine-2-one (100) onto chlorospiropentylideneacetates 2 c [21]...

Chiral carboxyamides derived from acid chlorides and A-chiral cA-aminoindanol can be protonated and Li Cu transmetallated to generate copper enolates which react with A-lithium derivative of A-Boc-O-tosylhydroxylamine (LiBTOC) 31 to give a-A-Boc amino carboxamides in high yields and enantiomeric excess (Scheme 38) . The chiral auxiliary can be removed by acidic hydrolysis to obtain the a-aminocarboxylic acid. 

It has become the custom to name linear aliphatic polyamides according to the number of carbon atoms of the diamine component (first named) and of the dicarboxylic acid. Thus, the condensation polymer from hexamethylenedi-amine and adipic acid is called polyamide-6,6 (or Nylon-6,6), while the corresponding polymer from hexamethylenediamine and sebacoic acid is called polyamide-6,10 (Nylon-6,10). Polyamides resulting from the polycondensation of an aminocarboxylic acid or from ring-opening polymerization of lactams are indicated by a single number thus polyamide-6 (Nylon-6) is the polymer from c-aminocaproic acid or from e-caprolactam. 

LACTAMIZATION REACTION OF AMINOCARBOXYLIC ACIDS CATALYZED BY (3,4,5-TRIFLUOROPHENYL)BORONIC ACID ... 

A review of the methods which facilitates the rapid choice of an optimum procedure to be used for the determination of procaine and other medicinals derived from aminocarboxylic acids has have been published [28]. This review covers volumetric, optical, electrochemical and polarographic methods. 

---