2, 3-Dimercaprol

Thiols have a marked ten dency to bond to mercury and the word mercaptan comes from the Latin mer curium captans which means seizing mercury The drug dimercaprol is used to treat mercury and lead poisoning It IS 2 3 dimercapto 1 propanol... [Pg.648]

Barbiturates such as amobarbital inhibit NAD-hnked dehydrogenases by blocking the transfer from FeS to Q. At sufficient dosage, they are fatal in vivo. Antin cin A and dimercaprol inhibit the respiratory chain between cytochrome b and cytochrome c. The classic poisons H2S, carbon monoxide, and cyanide inhibit cytochrome oxidase and can therefore totally arrest respiration. Malonate is a competitive inhibitor of succinate dehydrogenase. [Pg.95]

Figure 12-7. Proposed sites of inhibition (0) of the respiratory chain by specific drugs, chemicals, and antibiotics. The sites that appear to support phosphorylation are indicated. BAL, dimercaprol. TTFA, an Fe-chelating agent. Complex I, NADHiubiquinone oxidoreductase complex II, succinate ubiquinone oxidoreductase complex III, ubiquinohferricytochrome c oxidoreductase complex IV, ferrocytochrome ctoxygen oxidoreductase. Other abbreviations as in Figure 12-4.

Inhalation and dermal absorption mustards no antidote. For lewisite and ewisite/ mustard lmixtures British Anti-Lewisite (BAL or Dimercaprol) IM (rarely available). Thermal burn therapy supportive care (respiratory support and eye care). [Pg.191]

Gut I, Nerudova J, Kopecky J, et al. 1975. Acrylonitrile biotransformation in rats, mice, and Chinese hamsters as influenced by the route of administration and by phenobarbital, SKF 525-A, cysteine, dimercaprol, or thiosulfate. Arch Toxicol 33 151-161. [Pg.109]

Carbon dioxide Sulfur dioxide Aliphatic hydrocarbons Aromatic hydrocarbons Cholinesterase inhibitors Paraquat Lead Arsenic Mercury Removal from exposure and administer oxygen Removal from exposure Removal from exposure Removal from exposure Atropine, pralidoxime Gastric lavage and dialysis Dimercaprol, penicillamine Dimercaprol, penicillamine Dimercaprol (elemental), penicillamine, dimercaprol (inorganic salts)... [Pg.26]

If HL (C03-A010) is involved, a BAL (British-anti-Lewisite, dimercaprol) solution or ophthalmic ointment may be beneficial if administered promptly. It may also decrease the severity of skin and eye lesions if applied topically within minutes after decontamination is complete (i.e., within 2-5 minutes postexposure). [Pg.155]

Dimercaprol (British Anti-Lewisite or BAL) is a colorless, viscous oily compound with an offensive odor used in treating arsenic, mercury, and gold poisoning. It displaces the arsenic bound to enzymes. The enzymes are reactivated and can resume their normal biological activity. When given by injection, BAL can lead to alarming reactions that seem to pass in a few hours. [Pg.67]

BAL British Anti-Lewisite. Dimercaprol, a treatment for toxic inhalations. [Pg.297]

Treatment—Patients should be decontaminated immediately prior to treatment using the decontamination method presented in Section 7.3.2. British Anti-Lewisite (BAL) dimercaprol antidote will alleviate some effects. It is available as a solution in oil for intramuscular administration to counteract systemic effects. It is not manufactured currently in the forms of skin and eye ointments.2... [Pg.80]

British Anti-Lewisite dimercaprol alleviates some effects (Ellison 2000)... [Pg.109]

Sb3+, SN41, Pb2+, Bi2+ (Dimercaprol) while soluble in alkaline medium... [Pg.168]

The treatment of metal poisoning is to administer a compound that binds the metal ion more strongly than does the group in the active centre of the enzyme. These compounds are known as chelating agents. For lead, the compound ethyl-enediaminetetraacetic acid (EDTA) is used. For mercury, dimercaptopropanol (dimercaprol) is used. [Pg.47]

Dimercaprol (BAL, British Anti-Lewisite) was developed in World War 11 as an antidote against vesicant organic arsenicals (B). It is able to chelate various metal ions. Dimercaprol forms a liquid, rapidly decomposing substance that is given intramuscularly in an oily vehicle. A related compound, both in terms of structure and activity, is di-mercaptopropanesulfonic acid, whose sodium salt is suitable for oral administration. Shivering, fever, and skin reactions are potential adverse effects. [Pg.302]

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