1-Diisopropylamino-2,2-dimethyl

Diisopropylamino(dimethyl)silyl]-2-propenyl]lithium adds to aromatic and x-branched aldehydes in the presence of anhydrous zinc chloride with essentially complete anti stereoselectiv-ity3s. as expected from the chair-like pericyclic transition state formed by the ( -intermediate. The addition products are not isolated, but after O-silylation, oxidative desilylation with retention of configuration forms the rmft-diols. 

An analogous stereochemical outcome was observed when the ethylation of racemic 2-phenyl-propanal was catalyzed by (-)-(/ )-l-(diisopropylamino)-3,3-dimethyl-2-butanol36. The reaction was run to 70% conversion and again the ratio of syn- to anff-diastercomers was 3 1. In this case, however, the 7 -configurated aldehyde was predominantly consumed and both enantiomers of the aldehyde were predominantly alkylated from the Re-side. The optical purity of the unreacted (S)-2-phenylpropanal was 85.7% ee. 

HN-2) 2-(Diisopropylamino)ethanethiol Dimethyl isopropylphosphonate Cyclopentyl methylphosphonofluoridate Isopropyl trimethylsilyl 5842-07-9 7284-82-4 1115.8 1244.6... 

The G-nerve agents include GA (tabun, ethyl A,A-dimethyl-phosphoramidocyanidate), GB (sarin, isopropyl-methylphosphonofluoridate), GD (soman, 1,2,2-tri-methylpropyl methylphosphonofluoridate), and VX (o-ethyl 5-[2-(diisopropylamino)ethyl] methylphosphonothiolate). The V-type nerve agents are several orders of magnitude less volatile than the G-type agents and act primarily as a liquid via the percutaneous route for example, VX is several orders of magnitude more lethal percutaneously than sarin (Reutter, 1999). 

Isocyanid N-Diisopropylamino- E5, 1644 (R2N-NH-CHO/COCl2) 1-Penten 3-(Dimethyl-hydrazono)-E14b, 488 (aus Keton)... 

Amin tert.-Butyl-[2-(2,2-dimethyl-propanoyloxy)-butyliden]- E14b, 259 (Nitron + R-CO-C1) Cyclohexan l-(Diisopropylamino-carbonyl)-1-hydroxy- EI9d, 661 (H - Li/ -t- Keton)... 

CHLOROETHYL)-N-(l-METHYLETHYL)-2-PROPANAMINE HYDROCHLORIDE 2-(DIISOPROPYLAMINO)ETHYL CHLORIDE HYDROCHLORIDE 2-PROPANAlVIINE, N-(2-CHLOROETHYL)-N-(l -METHYLETHYL)-, HYDROCHLORIDE TRIETHYLAMINE, 2"-CHLORO-1,1 -DIMETHYL-, HYDROCHLORIDE... 

Stable [bis(diisopropylamino)phosphanyl](trimethylsilyl)carbene reacted readily with electron-poor alkenes, such as methyl acrylate and dimethyl ( )-but-2-enedioate leading to methyl 2-[bis(diisopropylamino)phosphanyl]-2-trimethylsilylcyclopropanecarboxylate (2) in 95% yield and dimethyl 3-[bis(diisopropylamino)phosphanyl]-3-trimethylsilylcyclopropane-/ra s-l, 2-... 

In sharp contrast to the coupling of the l,2-bis(diisopropylamino)-3-lithiocyclopropenylium ion 10 with the chlorocyclopropenylium ion containing rather bulky alkylamino substituents, the reaction with the 3-chloro-l,2-bis(dimethylamino)cyclopropenyliuin ion 18 took a completely different course i.c. a nucleophilic attack at the amino-substituted carbon of the chlorocyclopropenylium ring, a ring cleavage, then a second nucleophilic attack at the other amino-substituted carbon, followed by protonation. The whole reaction afforded the 1,3-bis-[2,3-bis(diisopropylamino)cyclopropenyliumyl]-l,3-bis(dimethylamino)propenylium trication 20 142 Trication 20 was also prepared by the reaction of two equivalents of l,2-bis(diiso-propylamino)-3-lithiocyclopropenylium perchlorate (10) with l,3-dichloro-l,3-bis(dimethyl-amino)allyl cation 19. 

Diisopropylamino-thiocarbonylthio)-3-(2,2-dimethyl-propanoylamino)-pyridin laBt sich mil ethanolischer Natronlauge in ein Gemisch aus 2-Mercapto- (86%) und 2-Diisopropylammo-yrido[4,3-d]-l,3-thiazol) (14%) uberfuhren79 ... 

Ausnahmen sind die Synthesen des 4-Diisopropylamino-2,3-dimethyl-1 -phenyl-5-py-razolon aus Aceton und 4-Amino-2,3-dimethyl-l-phenyl-5-pyrazolon14 und die von N,N-Dialkyl-anilinen durch reduktive Aminierung von Alkanonen in Form ihrer Acetale mit Anilinen13 (vgl. S. 452). So erhalt man z.B. N,N-Diisopropyl-anilin aus 2,2-Dimethoxy-propan und Anilin iiber Palladium/Kohle (5%) (120 bar/50°) zu 56% d.Th. Mit zunehmender Kettenlange der Acetale sind die Reaktionsbedingungen auf 135-155° und 100 bar zu steigern15. 

Bertrand s approach to the stable earbene problem has been to seareh for a most delieate balance of stability and reaetivify, such that the essential reaetions expeeted of a earbene are not lost. Carbene 42, for example is a distillable red oil that behaves as a nucleophilie earbene despite its phosphaaeefylene eontributing resonance form it undergoes addition to electron poor olefins (e.g., dimethyl fiimarate). The very eleetron-rieh bis(diisopropylamino)phosphino substituent damps the carbene s electrophliie properties by resonanee donation into the ear-benic p orbital. [115] These phosphinosilylcarbenes are therefore best deseribed by phosphorus vinyl ylide structures with a lone pair on earbon (ef, 42, seeond contributor). [116]... 

Two types of SPME fibers (Supelco, Inc.) were evaluated for each analyte 100-pm polydimethyl-siloxane and 85-pm polyacrylate coatings. Samples were then analyzed directly by GC-MS (Varian Saturn IV D) or derivatized on fiber first, then analyzed by GC-MS. The on-fiber derivatization procedure is accomplished by gently coating the SPME fiber with N,0-bis(trimethylsilyl)-trifluoroacetamide (BSTFA) prior to GC-MS analysis. The sample matrices analyzed in this study included soil leachate (sandy loam, Oakley, CA), simulated sea water (Instant Ocean, Aquarium Systems Co., Mentor, OH), and canal water (rain runoff, Livermore, CA). The chemical signatures we selected for the proliferation of CW included dimethyl methylphosphonate (DMMP), diisopropyl methylphosphonate (DIMP), 1,4-dithiane, thiodiglycol (TDG), and 2-(diisopropylamino)ethanol (DIAE). 

Amination of 2,3-diiodo-5,6-dimethylbenzene-l,4-diol with i-PrNH2 gave 3,6-bis(isopropylamino)toluquinone as the only product (eq 26) Amination of the same substrate with n-BuNH2 afforded a mixture of 2,3-dimethyl-6-(n-butylamino)-l,4-benzoquinone and 3,6-bis(n-butylamino)-toluquinone (eq 21)P The latter was formed from the reaction of 2,3-dimethyl-6-(n-butylamino)-l,4-benzoquinone in refluxing w-BuNH2 in air in 100% yfleld (eq 29). A mixture of l-isopropyl-2,5,6-trimethylindole-4,7-quinone and 5,6-bis((diisopropylamino)methyl)-2,3-diiodohydroquinone was formed in the reaction with (i-Pr)2NH (eq 28). ... 

A, A -Dihydroxy-2,3-dimethyl-2,3-butanediamine, D-00578 2-(Diisopropylamino)benzoic acid hydrazide, D-00747... 

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