Digestive tract symptoms

Koelsch (Ref 16), based on observation of 1200 workers engaged in handling PA, described the symptoms of poisoning as follows a yellow coloration of unprotected parts of the skin and hair, irritation of the mucous membranes and of the upper parts,of the respiratory tract and the digestive tract. In addition, a constant bitter taste and a lack of appetite appear... 

Antiflatulents are used for die relief of painful symptoms of excess gas in the digestive tract. These drugs are useful as adjunctive treatment of any condition in which gas retention may be a problem (ie, postoperative gaseous distention, air swallowing, dyspepsia, peptic ulcer, irritable colon, or diverticulosis). In addition to its use for tiie relief of intestinal gas, charcoal may be used in the prevention of nonspecific pruritus associated with kidney dialysis treatment and as an antidote in poisoning. Simethicone is in some antacid products, such as Mylanta liquid and Di-Gel liquid. 

One more example of acute polychlorpinen poisoning occurred in the Ukraine around 1969-70, when 27 women aged 26-49 were sent out to sow collective farm fields three days after the fields had been treated with polychlorpinen. A warm rain washed the pesticide from the soil, and the pesticide evaporated intensively. All the women showed symptoms of acute poisoning 20-40 minutes later eight lost consciousness, and nine had fits. The poisoned women spent from 3-25 days in the regional hospital, after which they all went to the VNIIGINTOKS clinic with disruptions of the neural and cardio-vascular systems, as well as of the digestive tract over the next 9-13 months [43]. 

Generally, tin compounds of 3-4 mgday-1 are ingested in the human body, and are absorbed poorly from the digestive tracts. 40% of the tin are excreted via urine and feces. Tin compounds tend to accumulate in liver, kidney and bone. By the oral route, high levels of tin compounds cause gastrointestinal symptoms such as nausea, vomiting and abdominal pain and headache. 

When Liver-Qi attacks the Stomach and Large Intestine, the Qi moves improperly in the digestive tract and the above-mentioned symptoms may arise suddenly. Alternatively, constipation and diarrhea may occur. 

Apart from skin injuries the symptoms of poisoning by chlorodinitrobenzene are similar to those produced by dinitrobenzene, namely general bodily weakness, cyanosis, a decrease of the number of red blood cells, disturbances in the functioning of digestive organs and heart failure. Treatment and recovery sometimes prove most difficult especially with regard to the digestive tract and the heart, whereas skin lesions are relatively easier to heal. 

The lethal dose of inorganic fluoride is estimated to be in the range of 2.5 to 5 g for a 70-kg man, or approximately 50 mg/kg, a dose similar to the LD50 for several animal species. The cause of death is probably related to the prompt binding of serum Ca and Mg by F. Clinical symptoms include excessive salivation, perspiration, nausea, painful spasms of limbs, stiffness, chronic convulsion, necrosis of mucosa of digestive tract, and heart failure. 

Elemental mercury is mainly hazardous as vapor. There is less danger of absorbing the metal for the digestive tract. Like the alkylmercurials, elemental Hg affects the central nervons system, accompanied with such symptoms as tremors, irritability, and sleeplessness. Kidney damage is also reported due to influence of inorganic mercury salts due to a complexation of mercury by the protein metallothionein, which accumulates in the renal tubules. 

Mode of Action. Despite the wide spectrum of insect host range activities displayed by Bt varieties, the mode of action of the insecticidal delta endotoxins is similar. When susceptible insects ingest Bt protein crystals, the first gross symptom observed is feeding inhibition due to paralysis of the digestive tract, including mouth parts. This usually occurs within one hour of ingestion ( ). 

Arachidonic acid (20 4n - 6) is one of two major PUFA synthesized by the D6D/D5D pathway (Fig. 4). In many tissues and cell types, 20 4n - 6 is esterified to the sn-2 position of membrane PL, and is used for the eicosanoid-mediated signaling to perform specialized cell functions. Arachidonic acid esterified in PL is a storage form of this fatty acid and is hydrolyzed from the PL by phospholipases prior to enzymatic conversion into eicosanoids (Chapter 13). Eicosanoids are autocrine/paracrine hormones that mediate a variety of localized reactions, such as inflammation, homeostasis, and protection of digestive tract epithelium. D6D deficiency in humans leads to severe food intolerance and growth retardation (J. Nwankwo, 2003). These symptoms are reversed by arachidonic acid supplementation to the diet, which supports the essential role of eicosanoids in the protection of digestive tract mucosa in humans. 

Simethicone is an antifiatulent that relieves flatulence by dispersing and preventing formation of mncns-snrronnded gas pockets in the GI tract. It is indicated in relief of painful symptoms and pressnre of excess gas in the digestive tract. It is an adjunct in treatment of many conditions in which gas retention may be a problem, snch as postoperative gaseous distention and pain, endoscopic examination, air swallowing, functional dyspepsia, peptic nicer, spastic or irritable colon, and diverticulosis. 

It is estimated that the dietary gold intake is < 7 J-g per day, and the absorption of gold compounds from the alimentary tract and skin is also poor (Iyengar etal. 2000). Of the more common medicinal gold compounds, only Auranofin - which shows good lipid solubility - can be absorbed through the intestine. The toxic symptoms appear as disorders in the digestive tract... 

HEALTH SYMPTOMS inhalation (irritation of respiratory tract, blue discoloration of fingertips, cheeks, nose, and lips, nausea, vomiting, headache, drowsiness, delirium, coma, shock) skin absorption (ataxia, dyspnea) ingestion (tachycardia, irritation of digestive tract). 

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