Diethyl amino groups

The chemistry of cyclophosph(m)azanes has been reviewed. The cyclo-phosph(m)azane (51) or (52) is the main product from the reaction of phosphorus trichloride with ethylamine, depending on the stoicheiometry. Both (51) and (52) have been isolated and characterized. Further studies of the reactions of disilylated ureas with chlorophosphines have resulted in a new bicyclic bis-aminophosphine (53). Diazaphosphetidines (54), diazadiphosphetidines (55), and thiadiazaphosphetidines (56) have been prepared by exchange of diethyl-amino groups with the appropriate diamide. ... 

Methacrylamide monomers were chosen due to their hydrolytic stability, structural similarity to amino acids found in naturally occurring AMP, incorporation of hydrophobic and hydrophilic moieties, and pKa values. APMA was chosen due to its similarity to lysine. While ionic bonding facilitates initial polymer-cell interactions, it is the hydrophobic substituents that act to disrupt the lipid membrane of bacteria. DMAPMA and DEAPMA were chosen due to their hydrophobic dimethyl and diethyl amino groups, respectively. Copolymers were formed by copolymerising APMA with DMAPMA and APMA with DEAPMA at varying ratios. 

Aminoacridine and a series of derivatives with N-9 aliphatic side chains unsubstituted, or 03-substituted with hydroxy and diethyl-amino groups have been recently submitted to biological essays (1-2). 

More recently Klotz s group (23,24) have reported esterolytic catalysis by polyethylenimine derivatives containing pendant diethyl-amino groups and functionalized triazine derivatives which exhibit increased catalytic effectiveness due to cooperative effects and increased apolar binding. 

A relatively uncontrolled attempt to enhance the colour yield and fastness to washing of selected direct dyes involved addition to the dyebath of a colourless reactant that was intended to form covalent attachments between these dyes and hydroxy groups in cellulose [135]. Most of the dyes selected contained at least two primary amino groups in aminonaphthol residues. The reactants evaluated were cyanuric chloride (7.3), N,N-diethyl-3-hydroxyazetidinium chloride (7.124) and 2,4-dichloro-6-(4,-sulphoanilino)-s-triazine (7.125), all of which will indeed react readily with primary arylamines. Some of the dyes selected, however, contained only diphenylurea or salicylic acid residues and these are most unlikely to react efficiently under dyeing conditions. 

The reaction between the sodium salt of diethyl 2-[2-(N-substituted amino)-4-thiazolyl]malonate (298) and diethyl chloromethylenemalonate in THF at ambient temperature for 1-10 hr occurred on the central carbon atom of the malonate (298), not on the amino group, to give tetraesters (299) in 10-70% yields (86EUP168025). 

In the cyclocondensation of diethyl acetylmalonate and 4-alkylamino-1,5-benzodiazepines (1411) in benzene in the presence of acetic acid and piperidine, the addition of acetylmalonate at the side-chain double bond of 1411 took place first. The amino group at position 4 was involved only in the second step of the reaction sequence to give tricyclic derivatives (1412) in 49-77% yields (85FES391). 

Diethyl dl-1 -aminobenzylphosphonate has been prepared by a Mannich reaction of diethyl phosphite, benzaldehyde, and ammonia, resolved as its D-mandelate salt, and hydrolysed to give (+)-l-aminobenzylphosphonic acid.27 While the tetraethyl-diamide (33) reacts with benzaldehyde to give the expected phosphonic diamide (34), the corresponding tetramethyl-diamide reacts, with migration of the dimethyl-amino-group, to give (35).28... 

DEAE is the abbreviation for DiEthyl Amino Ethyl, the binding group of a substitution on cellulose. SDS/PAGE is a technique for naming the material used for electophoresis in which SDS represents sodium dodecyl sulfate solution that is used with PolyAcrylimide Gel Electrophoresis (PAGE). 

POE 6000 was used as polymeric support, a soluble polyethylene glycol derivative functionalized at both termini with an amino group and with an average molecular mass of 6000 Da [62-63]. After completion of the homogeneous reactions it can be precipitated, filtered off, and washed with diethyl ether, thereby facilitating the separation of surplus reagents and the side products. Furthermore it allows for NMR spectroscopic monitoring of the reactions [64]. 

The 4-amino group of 145 is readily monoacylated with acyl or sulfonyl chlorides and isocyanates or isothiocyanates ethyl acetoacetate and diethyl malonate yield, respectively, 159 and 160. Hydrazides 161 undergo a re-... 

This work has been extended from aryl and alkyl substituted systems (42) (R = aryl, alkyl) to analogues where R is an amino group, so giving access to synthetic equivalents of the nonstabilized amino nitrile ylides (45). Adducts were obtained in good-to-moderate yield with A-methyhnaleimide (NMMA), DMAD, electron-deficient alkenes and aromatic aldehydes (27,28), and with sulfonylimines and diethyl azodicarboxylate (29). Similarly the A-[(trimethylsilyl)methyl]-thiocarbamates (46) undergo selective S-methylation with methyl triflate and subsequent fluorodesilylation in a one-pot process at room temperature to generate the azomethine ylides 47. 

Tris(diethyl)amino]phosphoniuni 2,2,3,3,4,4-hexafluorocyclobutane ylide (2) is a very hydroscopic solid, which is stable for long periods of time when stored under anhydrous conditions.13 It is unreactive towards most functional groups such as C = C bonds, ketones, aldehydes, and esters but reacts smoothly under neutral conditions with alcohols or carboxylic acids with replacement of the hydroxy group by a fluorine atom.44,45 Other tris(dialkylammo-nium)phosphonium perfluorocyclobutanes have been synthesized however, they are less reactive fluorinating reagents.44,45... 

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