Fluorine reactivity

Nucleophilic Displacement Reactions. The presence of activating groups, eg, o,p mX.1.0 groups, makes aromatic fluorine reactive in nucleophilic displacement reactions. This has been demonstrated by deterrnination of the relative fluorine—chlorine displacement ratios from the reaction of halonitroben2enes with sodium methoxide in methanol (137) F is displaced 200—300 times more readily than Cl. 

Saturable dye absorber, 14 677 Saturated aqueous salt solution, 9 34 Saturated calomel electrode (SCE), 9 571 Saturated fatty acids, 10 829, 830 Saturated hydrocarbons adsorbent affinity, 1 674 adsorption by zeolites, 1 624 fluorine reactivity with, 11 831 isomerization of, 12 172—173 Saturated polyester resins, based on trimethylpentanediol, 12 673 Saturated polyesters, 10 7 Saturated synthetic rubber, 10 705 Saturation and coating processes, 10 12-13 Saturation bonding, 17 509-510 Saturation color, 19 262 Saturation concentration, 15 677 Saturation index... 

Fluorination by cleavage of ethers has been investigated with a variety of hydrogen fluoride/ amine systems. Thus, the fluorinating reactivity is as follows ... 

Systematics and Surprises in Bond Energies of Fluorinated Reactive Intermediates... 

Kimoto H, Cohen LA (1979) Fluorine reactivity in 2-(trifluoromethyl)imidazoles. J Org Chem 44 2902-2906... 

Jeong et al. (2009) synthesized fluorinated reactivators (29-30 Figure 72.24) to increase their BBB penetration. For housefly AChE, some fluorinated compounds turned out to be potent reactivators of paraoxon-inhibited enzyme. BBB penetration was examined only via quantum mechanical calculations that supposed increased lipophilicity of prepared compounds. 

FIGURE 72.24 Fluorinated reactivators from a study in South Korea Qeong et al., 2009). 

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