Diazepam-binding inhibitor

Costa, E and Guidotti, A (1991) Diazepam binding inhibitor (DBI) a peptide with multiple biological actions. Life Sci. 49 325-344. 

Do Rego, JL, Mensah-Nyagan, AG, Feuilloley, M, Ferrara, P, Pelletier, G and Vaudry, H (1998) The endozepine triakontatetraneuropeptide diazepam-binding inhibitor [17-50] stimulates neurosteroid biosynthesis in the frog hypothalamus. Neuroscience 83 555-570. 

Reddy, DS and Kulkarni, SK (1998) The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice. Psychopharmacology 137 391-100. 

Herzog CD, Stackman RW and Walsh TJ (1996). Intraseptal flumazenil enhances, while diazepam binding inhibitor impairs, performance in a working memory task. Neurobiology of Learning and Memory, 66, 341-352. 

Avallone R, Zeneroli ML, Venturini I, Corsi L, Schreier P, Kleinschnitz M, Ferrarese C, Farina F, Baraldi C, Pecora N, Frigo M, Baraldi M Endogenous benzodiazepine-like compounds and diazepam binding inhibitor in serum of liver cirrhosis patients with and without encephalopathy. Gut 1998 42 860-867. 

GABAergic mechanisms Increased diazepam binding inhibitor mRNA GABA-B agonist does not affect nicotine withdrawal Endocannobioids D9-tetrahydrocannobinol decreased mec- and naloxone-precipitated withdrawal... 

Jonkman S, Markou A (2006) Blockade of nicotinic acetylcholine or dopamine D 1-fike receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminads does not precipitate nicotine withdrawal in nicotine-dependent rats, Neurosci Lett 400 140-145 Katsura M, Shuto K, Mohri Y, Tsujimura A, Ohkuma S (2001) Withdrawal from nicotine facilitates diazepam binding inhibitor mRNA expression in mouse cerebral cortex. Brain Res Mol Brain Res 97 194-218... 

Inverse agonists (P-carbolines) — Diazepam binding inhibitor T... 

Diazepam-displacing activity in human cerebrospinal fluid Diazepam-binding inhibitor (DBI)... 

Barbaccia, M. L., Berkovich, A., Guameri, P. and Slobodyansky, E. Diazepam binding inhibitor the precursor of a family of endogenous modulators of GABA-A receptor function. History, perspectives and clinical implications. Neurochem. Res. 15 (1990) 160-173. 

As the SCCE described above (Section 6.3.1.1) maybe part of a protein complex in the mitochondria, more effort was directed to study the possible interaction partners, especially the peripheral-t)q)e benzodiazepine receptor (PBR) (Papadopoulos et al, 1997 Koch, 2002) and the acyl-CoA-binding protein (ACBP Metzner et al, 2000). The ACBPs bind to the peripheral-t)q)e PBR present in the envelope of mitochondria (Gamier et al, 1994). This interaction stimulates the transport of cholesterol into mitochondria (Papadopoulos and Brown, 1995). The cholesterol taken up into the mitochondria is available as a substrate to the side-chain cleavage enzyme which transforms cholesterol into pregnenolone (Papadopoulos et al, 1997). Because of its interaction with PBR, ACBP is also described as diazepam-binding inhibitor or endozepine. Some isoforms of the latter were isolated and characterized from D. lanata (Metzner et al, 2000). Lindemann and Luckner (1997) speculated that cardenolide formation is regulated mainly by the availability of cholesterol and its transport into mitochondria, where the P450scc is assumed to be located. 

Papadopoulos, V. and Brown, A. (1995) Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis. /. Steroid Biochem. Mol. Biol, 53, 103-10. 

Taupin V, Herbelin A, Descapms-Latscha B, Zavala E (1991) Endogenous anxiogenic peptide, ODN-diazepam-binding-inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes. Lumphokine Cytokine Res 10 7-13. 

Diazepam binding inhibitor (DBI) is a polypeptide with a molecular weight of 9 KD. It has been isolated from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from mitochondrial BZD receptor located on the outer mitochondrial membrane. This peptide is known for multiple biological effects [109]. 

Rocca, P., Bellone, G., Benna, P., Bergamasco, B., Ravizza, L., and Ferrero, P., Peripheral-type benzodiazepine receptors and diazepam binding inhibitor-like immunoreactivity distribution in human peripheral blood mononuclear cells, Immunopharmacology, 25, 163, 1993. 

Papadopoulos, V. (1993). Peripheral-type benzodiazepine/diazepam binding inhibitor receptor biological role in steroidogenic cell function. Endocr Rev 14, 222-240. 

Anxiety peptide, diazepam-binding inhibitor peptide. 

DAST, diethylaminosulfur trifluoride. DBIP, diazepam-binding inhibitor peptide. DBU, l,8-diazabicyclo[5.4.0]undec-7-ene. Deb, dichlorobenzyl. 

Rothstein JD, McKhann G, Guarneri P, Barbaccia ML, Guidotti A, Costa E. Hepatic encephalopathy and cerebrospinal fluid content of diazepam binding inhibitor (DBI). Ann. Neurol., 26, 57-62, 1989... 

---