Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Diabetes insipidus drug-induced

Both drugs are used in conjunction with other diuretics like thiazide or loop diuretics to augment natriuresis and reduce loss of potassium. Triamterene may be used in the treatment of congestive heart failure, cirrhosis and the edema caused by secondary hyperaldosteronism. Amiloride is also useful in lithium induced diabetes insipidus. [Pg.208]

When a 45-year-old man with severe lithium-induced diabetes insipidus developed hyperosmolar, nonketotic hyperglycemia, it was suggested that poorly controlled diabetes mellitus may have contributed to the polyuria (684). Prior contact with a female patient who had developed hyperosmolar coma secondary to lithium-induced diabetes insipidus (685) allowed physicians 4 years later to treat her safely after a drug overdose and a surgical procedure, by avoiding intravenous replacement fluids with a high dextrose content (despite stopping lithium several years earlier, the patient continued to put out 10 liters of urine daily) (686). [Pg.619]

Nephrogenic diabetes insipidus has been described in patients receiving foscarnet, either alone or associated with a distal renal tubular acidosis [66, 67, 68]. In fact, a recent review cited foscarnet as the second most common reported cause of drug-induced diabetes insipidus, second only to lithium [69]. In experiments using toad urinary bladders [70], serosal application of foscarnet enhanced water flow in the presence of submaximal ADH concentrations, but did not affect water transport in the absence of ADH or when maximal concentrations of ADH were used. Mucosal foscarnet did not affect water transport. Further studies are needed to clarify the mechanisms for altered water handling by the kidneys with foscarnet. [Pg.387]

Bendz FI, Aurell M. Drug-induced diabetes insipidus incidence, prevention and management. Drug Saf 1999 2 449-456... [Pg.394]

Walker RG. Lithium nephrotoxicity. Kidney Int Suppl 1993 42 S93-S98. LamSS, Kjellstrand C. Emergency treatment of lithium-induced diabetes insipidus with nonsteroidal anti-inflammatory drugs. Ren Eail 1997 19 183-188. [Pg.889]

Answer C. Neurogenic diabetes insipidus is treated with desmopressin, a drug that is similar to vasopressin (ADH) but a selective activator of V2 receptors in the kidney. Remember that V, receptors are present in smooth muscle, and their activation leads to vasoconstriction and bronchoconstriction. Nephrogenic diabetes insipidus (decreased response of vasopressin receptors) is treated with thiazides except in the case of that induced by lithium, when amiloride is preferred (because thiazides increase blood levels of lithium). [Pg.308]

Bendz H, Aurell M. Dmg-induced diabetes insipidus incidence, prevention and management. Drug Saf 1999 2 449-456. Hoch, BS, Shahmehdi SJ, Louis BM, Lipner HI. Foscarnet alters antidiuretic hormone-mediated transport. Antimicrob Agents Chemother 1995 39 2008-2012. [Pg.259]

Other side effects of sulfonylureas include nausea and vomiting, cholestatic jaundice, agranulocytosis, aplastic and hemolytic anemias, generalized hypersensitivity reactions, and rashes. About 10-15% of patients who receive these drugs, particularly chlorpropamide, develop an alcohol-induced flush similar to that caused by disulfiram see Chapter 23). Sulfonylureas, especially chlorpropamide, may induce hyponatremia by potentiating the effects of vasopressin on the renal collecting duct see Chapter 29), and this effect on water retention has been used to therapeutic advantage in patients with mild forms of central diabetes insipidus. [Pg.1052]

B. Chronic intoxication may occur in patients on stable therapeutic doses. Lithium is excreted by the kidney, where it is handled like sodium any state that causes dehydration, sodium depletion, or excessive sodium reabsorption may lead to increased lithium reabsorption, accumulation, and possibly intoxication. Common states causing lithium retention include acute gastroenteritis, diuretic use, use of nonsteroidal anti-inflammatory drugs or angiotensinconverting enzyme (ACE) inhibitors, and lithium-induced nephrogenic diabetes insipidus. [Pg.244]

Lawrence GD, Hsu T-H, Lichtenstein LM (1972) Diabetes insipidus with hypersensitivity to pitressin an immunological study. Johns Hopkins Med J 131 172-177 Lippmann M, Morgan WKC, Murphy DM (1973) Drug-induced pulmonary disease. Ann Intern Med 78 616... [Pg.711]


See other pages where Diabetes insipidus drug-induced is mentioned: [Pg.597]    [Pg.142]    [Pg.374]    [Pg.164]    [Pg.2102]    [Pg.389]    [Pg.159]    [Pg.250]    [Pg.494]    [Pg.116]   
See also in sourсe #XX -- [ Pg.775 ]

See also in sourсe #XX -- [ Pg.775 ]




SEARCH



Diabetes drugs

Drug-induced

Drug-induced diabetes

Insipidus

© 2024 chempedia.info