DI-TERT-BUTYL

Despite numerous attempts the alkene 3 4 di tert butyl 2 2 5 5 tetramethyl 3 hexene has never been synthesized Can you explain why Try mak mg a space filling model of this compound... 

Analog reagiert 3,4-Di-tert.-butyl-furazan-2-oxid mit Alkenen442bzw. 3,4-Bis-[phenylsulfonyl]-furazan-2-oxid443 mit Alkenen bzw. Alkinen444 ... 

On the other hand, some organic cation radicals can act as hydrogen atom donors. For example, one-electron oxidation of 1,3-cyclohexadiene (C6H8) by 3,4-di(tert-butyl)-4-chloro-l,2-benzoquinone leads to the formation of C6H8. In the presence of sulfur, dehy-droaromatization of the cation radical takes place (Berberova et al. 1998), Scheme 1-48 ... 

The inhibitory potencies, suggested by the present equations, appear to be significant if found within the range of those represented in the sample (Iso 10 - 10 ° M). Extrapolations to lower ranges of Isos are, however, not necessarily valid. Iso values for several 3,4-disubstituted 3-phenylthio-1,1,1-trifluoro-2-propanones, such as the 3,4-di-tert.butyl and 3,4-dicyclohexyl derivatives have been predicted even at the low range of 10 - 10 M. This prediction is against the observation that below 10 - 10 ° M range the inhibitory activity seems not to Increase with the llpophllicity. In the present study, no square terms, such as (X r), , etc. 

Ethoxy-4,4-diroethyl-l,2-pentadiene, 167 - (35) 3,4-Di-tert.-butyl--1,2,4,5-hexatetraene, 168 - (37) 3-Tr1raethylsilyl-l,2-heptadiene, 169... 

Di-tert-butyl-l,2-dithiete was obtained by heating 2,2,5,5-tetramethylhex-3-yne (di-tert-butyl acetylene) with sulfur in benzene in an autoclave at 190 °C [24]. It is thermally stable and exists in the dithiete form. Valence isomerization into the dithione form would enhance the steric strain in the molecule. 

Tetrasubstituted thiophene 3,4-di-tert-butyl-2,5-dimethylthiophene 1-oxide reacted with maleic anhydride to give the Diels-Alder adduct quantitatively... 

The first synthesis of 3,4-di-tert-butyl-l,2-dithiete (172) was performed by treatment of 173 with Lawesson s reagent (LR). Direct thionation of the diketone 174 failed to yield 172 [82JCR(S)314]. 

SILICON AND SILICON ALLOYS - CHEMICAL AND TffiTALLURGICAL] (Vol21) Calciumbis[0-ethyl(3,5-di-tert-butyl-4-hydroxybenzyl)phosphonate] [65140-91-2]... 

Phenol is a radical scavenger . Other radical scavengers include 3,5-di-tert-butyl-4-hydroxytoluene (butylated hydroxytoluene or BHT) and vitamin E. 

Bis(3,5-di-tert-butyl-4-hydroxyphenyl) acetone mercaptole, melting at 125°C to 126°C is prepared by employing 2,6-di-tert-butyl-4-mercaptophenol and acetone as starting materials. In one representative procedure, the 2,6-di-tert-butyl-4-mercaptophenol (47.5 g, 0.2 mol) is dissolved in methanol (50 ml) heated at a temperature of 50°C. A catalytic amount of concentrated hydrochloric acid (1 ml) is added, followed by acetone (5S g,0.1 mol). The temperature of the mixture rises to about 60°C, and is maintained at about 60°C to 65°C for 1.5 hours. The mixture is cooled, diluted with water and about 10 ml of aqueous sodium bicarbonate and extracted with ether. The ether extract is evaporated, and the product is obtained as a residue, which is recrystallized from ethanol and then from isopropanol to obtain the bis(3,5-di-tert-butyl-4-hydroxyphenyl) acetone mercaptole as a crystalline solid melting at about 125°Cto 126°C. 

In another representative procedure about 2.3 mols of 2,6-di-tert-butyl-4-mercaptophenol is dissolved in about 1,700 ml of methanol under a nitrogen atmosphere about 100 ml of concentrated hydrochloric acid and 1B0 ml of acetone are added, and the mixture is stirred and maintainedat a temperature of about 35°C to 50°C, for 1.5 hours. The mixture is then cooled to room temperature and filtered, and the bis(3,5-di-tert-butyl-4-hydroxyphenyl) acetone mercaptole product is collected as a colorless crystalline solid filter cake. The product is washed with water and aqueous sodium bicarbonate and purified by recrystallization from ethanol. 

Di-tert-butyl-4-hydroxyphenyl)-7//-triazolo [3,2-b][l, 2,4]triazin-7-one (HWA-131)is anon-immunosuppressive drug that effectively inhibited carrageenan-induced paw edema, attenuated the active Arthus reaction, and demonstrated antierythema as well as antipyretic activity. Part of the antiinflammatory effect of this new compound is most probably related to its antioxidative activity as well as inhibition of lipoxygenase... 

B. 2-Chloro-3,6-di-tert-butyl-l,4-benzoquirwne. A 2-1. Erlenmeyer flask is charged with a solution of 112 g. (0.385 mole) of 2,3-dichloro-2,5-di-fer<-butylcyclohex-5-ene-l,4-dione in 800 ml. of ether. A solution of 28.4 g. (0.383 mole) of diethylamine (N-ethylethanamine) in 50 ml. of ether is added in one portion to the vigorously swirled flask (Note 5). The reaction is instantaneous, resulting in a voluminous precipitate. The mixture is washed with two 1-1. portions of water and then with 500 ml. of aqueous saturated sodium chloride. The yellow ether solution is dried over anhydrous magnesium sulfate, the drying agent removed by filtration, and the solvent removed on a rotary evaporator to yield 96-97 g. (98-99%) of 2-chloro-3,6-di-ferf-butyl-l,4-benzo-quinone as a yellow oil which is used without further purification (Note 6). 

Note The contrast between the colored zones and the layer background can be improved by warming the chromatogram gently [4]. Di-tert-butyl peroxide does not react [3]. N,N,N, N -tetramethyl-p-phenylenediamine (q.v.) can also be used instead of N,N-DPDD for the detection of peroxides [3]. The spray solution for peroxides gradually turns dark red in color but it still retains its ability to react for several weeks [4]. 

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