Development rat cerebellum

Maeshima T, Shiga T, Ito R, Okado N. Expression of serotonin2A receptors in Purkinje cells of the developing rat cerebellum. Neurosci Res 2004 50 411-417. 

Ripellino, J.A. et al., Light and electron microscopic studies on the localization of hyaluronic acid in developing rat cerebellum, J. Cell Biol., 106, 845, 1988. 

Zagon IS, Gibo DM, McLaughlin PJ. 1991. Zeta (zeta), a growth-related opioid receptor in developing rat cerebellum Identification and characterization. Brain Res 551 28-35. 

Cambray-Deakin MA, Foster AC, Burgoyne RD (1990) The expression of excitatory amino acid binding sites during neuritogenesis in the developing rat cerebellum. Dev. Brain Res., 54, 265-271. 

Cohen-Cory S, Dreyfus CF and Black IB (1989) Expression of high- and low-affinity nerve growth factor receptors by Purkinje cells in the developing rat cerebellum. Exp. Neurol, 105, 104-109. 

D Angelo E, Rossi P, Taglietti V (1993) Different proportions of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor currents at the mossy fibre-granule cell synapse of developping rat cerebellum. 

Legrand Ch, Thomasser M, ParkesCO, Clavel MC, Rabie A(1983) Calcium binding protein in the developing rat cerebellum. Cell Tissue Res., 233, 289-402. 

Van den Dungen HM, Groenewegen HJ, Tilders FJH, Schoemaker J (1988) Immunoreactive corticotropin releasing factor in adult and developing rat cerebellum its presence in climbing and mossy fibres. J. Chem. Neuroanat., 1, 339-349. 

Mittal, B. and David, S. (1994b) The role of an astrocyte surface molecule in neuronal migration in the developing rat cerebellum. Mol. Cell. Neurosci. 5 78-86. 

Heaton, M.B., Paiva, M., Mayer, J., euid Miller, R. (2002). Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum. Neurosci. Lett. 334 83-86. 

Lauder, J.M., 1979, Granule cell migration in the developing rat cerebellum. Influence of neonatal hypo- and hyperthyroidism, Dev. Biol.. 70 105. 

Legrand, C., 1976, Thyroid hormone and cell formation in the developing rat cerebellum, Biol. Neonate, 29 368. 

Although in the original method (Breitman, 1963) the counting efficiency was only 2% for (%)-labelled thymidine nucleotides, the technique has also been adopted for assaying thymidine kinase in developing rat cerebellum (Weichsel, 1974). As can be expected, their values are low in comparison with those works in which thymidine nucleotides were separated by thin-layer chromatography (Yamagami et al., 1972). Further-... 

In this chapter, we discuss several immunohistochemical methods to monitor apoptosis and autophagy in two models, the cultured rat neuroblastoma cells and the developing rat cerebellum. 

Pisu MB, Roda E, Guioli S et al (2005) Proliferation and migration of granule cells in the developing rat cerebellum cisplatin effects. Anat Rec A Discov Mol Cell Evol Biol 287 1226-1235... 

Mariani J, Changeux JP (1981) Ontogenesis of olivocerebellar relationships. I. Studies by intracellular recordings of the multiple innervation of Purkinje cells by climbing fibers in the developing rat cerebellum. J Neurosci 1 696-702... 

Southam, E., East, S. J., and Garthwaite, J. (1991). Excitatory amino acid receptors coupled to the nitric oxide/cyclic GMP pathway in rat cerebellum during development. 

Scherini E, Bemocchi G (1994) cisDDP treatment and development of the rat cerebellum. Prog Neurobiol 42 161-196. 

Fig. 28. Developmental expression of protein kinase C (PKC) isoenzymes in rat cerebellum. Immunofluores-cent staining of cerebellar cortex by antibodies specific for PKC 1, corresponding to PKCr (panels A, B and C), PKC (panels D, E and F) and PKCa (panels G, H and I), Sagittal sections of cerebellum of 1-week-old (A, D and G), 2-week-old (B, E and H) and 3-week-old (C, F and I) rats were used. PKCr antibody stained mainly the Purkinje ceil bodies and dendrites throughout the development. PKC/8 antibody stained the cerebellar granule cells in the external germinal layer (EGL) of the 1- and 2-week-old rats and mainly the granular layer of the 3-week-old rats. PKCa antibody stained both granule cells and Purkinje cells throughout the development. Fluang et al. (1991).

P75 nerve growth factor-receptor protein (NGF-R) is present in developing and adult Purkinje cells. Yan and Johnson (1988) and Cohen-Cory et ah (1989) described and reviewed the development of NGF-R in rat cerebellum. Low affinity NGF-R immunoreactivity has been demonstrated with species-specific monoclonal antibodies in Purkinje cells of adult rats (Pioro and Cuello, 1988, 1990 Pioro et ah, 1991 Fusco et ah, 1991 Dusart et ah, 1994), monkey and human brain (Mufson et ah, 1991). Immunoreactivity was present in the somata, dendrites and the proximal axon of the Purkinje cells. Additional immunoreactivity in granule cells was reported by Vega et ah... 

Altman J, Bayer SA (1985a) Embryonic development of the rat cerebellum. I. Delineation of the cerebellar primordium and early cell movements. J. Comp. Neurol., 231, 1-26. 

Gonzalez BJ, Leroux P, Laquerricre A, Coy DH, Bodenant C, Vaudry H (1988) Transient expression of somatostatin receptors in the rat cerebellum during development. Dev. Brain Res.. 40, 154-157. 

Kasa P, Bansaghy K, Rakonczay Z, Gulya K (1982) Postnatal development of the acetylcholine system in different parts of the rat cerebellum. J. Neurochem., 39, 1726-1732. 

Schoen SW, Graeber MB, Toth L, Kreutzberg GW (1991) Synaptic 5 -nucleotidase is transient and indicative of climbing fiber plasticity during the postnatal development of rat cerebellum. Dev. Brain Res., 61, 125-138. 

Wassef M, Sotelo C (1984) Asynchrony in the expression of cyclic GMP dependent protein kinase by clusters of Purkinje cells during the perinatal development of rat cerebellum. Neuroscience, 13, 1219-1243. 

Yamamoto T, Ishikawa M, Tanaka C (1977) Catecholaminergic terminals in the developing and adult rat cerebellum. Brain. Res., 132, 355-361. 

Viollet C, Bodenant C, Prunotto C, Roosterman D, Schafer J, Meyerhof W, Epelbaum J Vaudry H, Leroux P (1997) Differential expression of multiple somatostatin receptors in the rat cerebellum during development. J Neurochem 68 2378-2272 Wang H, Bogen C, Reisine T, Dichter M (1989) Somatostatin-14 and omato tatin-28 induce opposite effects on potassium currents in rat neocortical neurons. Proc Natl Acad Sci USA 86 9616-9620... 

A niunber of brain region proteomes have been studied to investigate differences in protein expression. Preliminary analysis of the mouse cerebellar proteome has identified 30 proteins (Beranova-Giorgianni, Giorgianni et al. 2002) and analysis of the porcine cerebellum led to identification of 56 spots (Friso and Wikstrom 1999). A developmental proteomic study of the rat cerebellum yielded resolution of over 3000 spots and identification of 67 of these (Taoka, Wakamiya et al. 2000). Most proteins showed an increase in abundance as the cerebellum matured, however, 42 spots appeared to be exclusively expressed in the immature cerebellum. Some of the latter were identified by MS and included proteins with defined roles in nervous system development. 

In primary cultures from developing rat or mouse cerebellum no such effects on proliferation of EGL cells has been demonstrated (Messer et al. 1984, 1985), although effects on the number of glial cells were found. However, it is not clear whether proliferation of EGL cells occurs at sufficient levels in these cultures to show effects even if they were present. Thus, this issue must await further clarification. Also there is some question as to whether all postnatal germinal zones respond to thyroid hormones in the same way (Seress, 1977, 1978). However, the presence of specific nuclear receptors for thyroid hormones during brain development, (see Chapter by DeNayer) is consistent with the possibility that effects of thyroid hormones on cell proliferation, where they do exist, could occur by direct interactions with the genome. 

Rabie, A., Favre, C., Clavel, M.C., and Legrand, J., 1977, Effects of thyroid dysfunction on the development of the rat cerebellum, with special reference to cell death within the internal granular layer. Brain Res., 120 521. 

J.P. Brion, J. Guilleminot, D. Couchie, J. Flament-Durand and J. Nunez. Both adult (52-70 kDa) and juvenile (48 kDa) Ihu microtubule associated proteins are axon-specific in the developing and adult rat cerebellum. Neuroscience (1988) in press. 

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