Developing agents universal developers

Procarbazine -alkylating agent cell cycle independent -bone marrow suppression—prolonged -nausea and vomiting—severe tolerance often develops with repeated dosing -mucocutaneous effects (mucositis, stomatitis, diarrhea) -rash, hives, photosensitivity -interstitial pneumonitis -CNS toxicity—seizures, lethargy, headache, ataxia -flu-like syndrome -azoospermia and amenorrhea almost universal... 

Because of the wide variety of potential toxins and their symptoms, there are no universal recommendations for triaging casualties exposed to toxins as a class. However, in general, anyone who has been exposed should be transported to a medical facility for evaluation. Individuals who are asymptomatic and have not been directly exposed to the agent can be discharged after their names, addresses, and telephone numbers have been recorded. They should be told to seek medical care immediately if symptoms develop. 

The end 70-ies was noted by the development of universal efficacious agents for the therapy of OPC affection, H-oximes or reactivators of the second generation, by means of structural modification of the first generation reactivators. The most efficacious compounds were synthesized in Germany under the direction off Hagedom [8],... 

There is no doubt that more and more agents will be developed because of their ability to hit tumor cells with a particular genetic signature. For example, recent work from Dr. Scott Kern s laboratory at Johns Hopkins University has indicated that pancreatic cancer cells with functional defects in the Fanconi anemia pathway (including BRCA-2 mutations) are... 

The aim of this review is to summarize the difficulties likely to be encountered in the LC separation of basic solutes, which include the majority of pharmaceutical and also many biomedically important compounds. An answer to the problem of the separation of the cinchona alkaloids, fit for purpose, was obtained on the Hypersil column by adding the silanol blocking agent hexylamine to the mobile phase, which allowed the extra separation power of the smaller particle column to be exploited [3]. However, alternative solutions to the problem, which will be explored in this review, are more appropriate in particular circumstances there is no universal solution that is applicable in all cases. The present review will concentrate on the most recent developments in this subject for the past few years. Further background information can be found in earlier reviews by the present author [4,5] and by Snyder [6]. 

Research carried out by the Queen s University of Belfast in the thermoforming of PP and PP foam is reviewed. Studies were made of the influence of crystallinity on thermoformability and the nse of chemical blowing agents in the production of foams having lower density and optimum cell stracture. Finite element modelling was nsed in the prediction of wall thicknesses and an optimised process control system was developed. BELFASUQUEEN S UNIVERSITY... 

Tuchmann-Duplessis, H. and and Mercier-Parot, L. (1971) Influence of neuroleptics on prenatal development in mammals. In Tuchmann-Duplessis, H., Fanconi, G., Burgio, G.R., eds. Malformations, Tumors and Mental Defects, Pathogenetic Correlation s. Milan Carlo Erba Foundation. As cited in Shepard, T.H. Catalog of Teratogenic Agents, 6th ed. Baltimore Johns Hopkins University Press, 1989, pp. 308-309. 

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